CD97 Products

Description

CD97, a CD55 Receptor, is a leukocyte antigen located on most activated leukocytes. CD97 is highly homologous to EMR2 with five EGF-like domains in the N-terminal extracellular domain, suggesting that it may be involved in cell signaling as well as in cell adhesion (Hamann et al., 1996). Two variants are produced by alternative splicing, where the shorter form lacks exons 5 and 6 and reduces the number of EGF-like domains from 5 to 3, compared to the full-length isoform. CD97 is associated with with the activated lesions of multiple sclerosis. CD97 expression is also implicated in the dedifferentiation of colon and thyroid tumors. CD97 is expressed abundantly in cells of hematopoietic origin and is markedly upregulated on activated T and B cells. ESTs have been isolated from a wide variety of tissue libraries.

Bioinformatics

Entrez	976 Human
Uniprot	AAH06676 Mouse AAH26690 Human NM_001784 Human NP_001775 Human NP_001775.2 Human NP_510966 Human P48960 Human
Product By Gene ID	976
Alternate Names	CD97 antigenseven-span transmembrane protein CD97 molecule Leukocyte antigen CD97 seven transmembrane helix receptor seven-transmembrane, heterodimeric receptor associated with inflammation TM7LN1

Research Areas for CD97

Find related products by research area and learn more about each of the different research areas below.

GPCR
Immunology