TSC2 Products

Description

Tuberous sclerosis complex-2 (TCS2 also known as Tuberin) is a tumor suppressor that forms a complex with TSC1 (Hamartin ) and this complex is known to control various cellular functions including cell cycle, endocytosis, adhesion, and transcription (1). The C-terminal region of TSC2 contains a GTPase-activating protein (GAP) domain which interacts with Rap1, Rab5 and Rheb (2). The TSC1/TSC2 complex inhibits phosphorylation of S6kinase and 4E-BP1 through inactivation of mTOR (3). Additionally, binding of 14-3-3 beta to TSC2 at Ser1210 reduce the ability of the complex to inhibit phosphorylation of S6 kinase (4). Phosphorylation by ATK at Ser924 and Thr1518 inactivates TSC2 and disrupts its interaction with TSC1 (5). Tuberous sclerosis (TSC), an autosomal dominant disorder that affects 1 in 6000 individuals, is caused by a mutation in either the TSC1 or TSC2 tumor suppressor gene.

Bioinformatics

Entrez	22084 Mouse 24855 Rat 7249 Human
Uniprot	NP_000539 Human P49815 Human
Product By Gene ID	7249
Alternate Names	LAMFLJ43106 TSC4 tuberin Tuberous sclerosis 2 protein tuberous sclerosis 2

Research Areas for TSC2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Autophagy
Cancer
Cell Cycle and Replication
Cytoskeleton Markers
Hypoxia
mTOR Pathway
Phospho-Specific
Signal Transduction
Tumor Suppressors

Related TSC2 Blog Posts

Check out the latest blog posts on TSC2.

Epigenetic Control of Autophagy By Christina Towers, PhD. In the last 20 years, epigenetic regulation has become front and center for almost all fields of biology and its role in diseases like cancer and neurodegeneration are being heavily studi...    Read more.

TSC2 - GTPase activating protein involved in cell cycle inhibition TSC2 is a tumor suppressor gene that encodes a 200 kDa protein called tuberin. TSC2 heterodimerizes with TSC1 to form a complex with GTPase-activating protein (GAP) activity. The C-terminus of TSC2 contains the GAP domain responsible for this cata...    Read more.

Read more TSC2 related blogs.