Name: TGF-beta RII Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-241-NA
Price: 509 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Flow, IHC, B/N, CyTOF-ready, ELISA(Cap)
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Alexa Fluor 700 FAB2411N-100

Alexa Fluor 700 FAB2411N-025

Allophycocyanin FAB2411A-100

Allophycocyanin FAB2411A-025

Biotin BAF241

Fluorescein FAB2411F-100

Fluorescein FAB2411F-025

Phycoerythrin FAB2411P-100

Phycoerythrin FAB2411P-025

Catalog# & Formulation	Size	Price
Carrier Free FAB2411F-100

Carrier Free FAB2411P-100

Carrier Free FAB2411A-100

Carrier Free FAB2411A-025

Carrier Free FAB2411F-025

Carrier Free FAB2411P-025

Carrier Free AF-241-SP

Carrier Free FAB2411N-100

Carrier Free FAB2411N-025

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 700	FAB2411N-100
Alexa Fluor 700	FAB2411N-025
Allophycocyanin	FAB2411A-100
Allophycocyanin	FAB2411A-025
Biotin	BAF241
Fluorescein	FAB2411F-100
Fluorescein	FAB2411F-025
Phycoerythrin	FAB2411P-100
Phycoerythrin	FAB2411P-025

TGF-beta RII Antibody [Unconjugated]

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TGF-beta RII Antibody [Unconjugated] Summary

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Publications for TGF-beta RII Antibody (AF-241-NA)(38)

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Bioinformatics

Immunogen	Mouse myeloma cell line NS0-derived recombinant human TGF‑ beta RII Ile24-Asp159 Accession # P37173.2
Specificity	Detects human TGF-beta RII in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	TGFBR2
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF-241-NA	Applications	Species
Windus, LCE;Matigian, N;Avery, VM; Induction of Reactive Bone Stromal Fibroblasts in 3D Models of Prostate Cancer Bone Metastases Biology 2023-06-15 [PMID: 37372146] (Western Blot, ICC, Human)	Western Blot, ICC	Human
Emy Bosseboeuf, Anissa Chikh, Ahmed Bey Chaker, Tom P. Mitchell, Dhilakshani Vignaraja, Ridhi Rajendrakumar et al. Neuropilin-1 interacts with VE-cadherin and TGFBR2 to stabilize adherens junctions and prevent activation of endothelium under flow Science Signaling 2023-05-23 [PMID: 37220183]
V Klück, G Cab?u, L Mies, F Bukkems, L van Emst, R Bakker, A van Caam, HINT conso, TO Cri?an, LAB Joosten TGF-beta is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells Arthritis Research & Therapy, 2023-02-27;25(1):30. 2023-02-27 [PMID: 36850003] (Neutralization, Human)	Neutralization	Human
ER Trzeciak, N Zimmer, PW Kämmerer, D Thiem, B Al-Nawas, A Tuettenber, S Blatt GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate Biomedicines, 2022-12-05;10(12):. 2022-12-05 [PMID: 36551892] (Functional Assay, Human)	Functional Assay	Human
SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456734] (Neutralization, Human)	Neutralization	Human
X Zhou, X Li, R Wang, D Hua, C Sun, L Yu, C Shi, W Luo, Z Jiang, W An, Q Wang, S Yu Recruitment of LEF1 by Pontin chromatin modifier amplifies TGFBR2 transcription and activates TGFbeta/SMAD signalling during gliomagenesis Cell Death & Disease, 2022-09-24;13(9):818. 2022-09-24 [PMID: 36153326] (Western Blot, Human)	Western Blot	Human
I Hanson, KE Pitman, U Altanerova, ? Altaner, E Malinen, NFJ Edin Low-Dose-Rate Radiation-Induced Secretion of TGF-beta3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding International Journal of Molecular Sciences, 2022-07-24;23(15):. 2022-07-24 [PMID: 35897723] (Neutralization, Human)	Neutralization	Human
N Ju, H Hayashi, M Shimamura, S Baba, S Yoshida, R Morishita, H Rakugi, H Nakagami Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice Scientific Reports, 2022-07-21;12(1):12474. 2022-07-21 [PMID: 35864207] (ICC, Human)	ICC	Human
Mengwen Zhang, Xingyi Pan, Kenji Fujiwara, Noelle Jurcak, Stephen Muth, Jiaojiao Zhou et al. Pancreatic cancer cells render tumor-associated macrophages metabolically reprogrammed by a GARP and DNA methylation-mediated mechanism Signal Transduction and Targeted Therapy 2021-10-29 [PMID: 34711804]
N Zimmer, FK Krebs, S Zimmer, H Mitzel-Rin, EJ Kumm, K Jurk, S Grabbe, C Loquai, A Tuettenber Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis Cancers, 2020-12-05;12(12):. 2020-12-05 [PMID: 33291452] (Cell Culture, Human)	Cell Culture	Human
LL Lin, ER Kost, CL Lin, P Valente, CM Wang, MG Kolonin, AC Daquinag, X Tan, N Lucio, CN Hung, CP Wang, NB Kirma, TH Huang PAI-1-Dependent Inactivation of SMAD4-Modulated Junction and Adhesion Complex in Obese Endometrial Cancer Cell Rep, 2020-10-13;33(2):108253. 2020-10-13 [PMID: 33053339] (CyTof, Human)	CyTof	Human
Aurore Devocelle, Lola Lecru, Hélène François, Christophe Desterke, Cindy Gallerne, Pierre Eid et al. Inhibition of TGF-beta 1 Signaling by IL-15: A Novel Role for IL-15 in the Control of Renal Epithelial-Mesenchymal Transition: IL-15 Counteracts TGF-beta 1-Induced EMT in Renal Fibrosis International Journal of Cell Biology 2019-07-07 [PMID: 31360169]
C Thepmalee, A Panya, M Junking, T Chieochans, PT Yenchitsom Inhibition of IL-10 and TGF-? receptors on dendritic cells enhances activation of effector T-cells to kill cholangiocarcinoma cells Hum Vaccin Immunother, 2018-02-21;0(0):0. 2018-02-21 [PMID: 29420117] (Neutralization, Western Blot, Human)	Neutralization, Western Blot	Human
OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien TGF-? contamination of purified recombinant GDF15 PLoS ONE, 2017-11-21;12(11):e0187349. 2017-11-21 [PMID: 29161287] (Neutralization, Human)	Neutralization	Human
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats PLoS ONE, 2016-08-30;11(8):e0161782. 2016-08-30 [PMID: 27575371] (Blocking, Rat)	Blocking	Rat
Clathrin light chains' role in selective endocytosis influences antibody isotype switching Proc Natl Acad Sci USA, 2016-08-18;0(0):. 2016-08-18 [PMID: 27540116] (Bioassay, Human)	Bioassay	Human
Kenny H, Chiang C, White E, Schryver E, Habis M, Romero I, Ladanyi A, Penicka C, George J, Matlin K, Montag A, Wroblewski K, Yamada S, Mazar A, Bowtell D, Lengyel E Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest, 2014-09-09;124(10):4614-28. 2014-09-09 [PMID: 25202979] (Neutralization, Human)	Neutralization	Human
Gate D, Danielpour M, Rodriguez J, Kim G, Levy R, Bannykh S, Breunig J, Kaech S, Flavell R, Town T T-cell TGF-beta signaling abrogation restricts medulloblastoma progression. Proc Natl Acad Sci U S A, 2014-07-31;111(33):E3458-66. 2014-07-31 [PMID: 25082897] (IHC, Human)	IHC	Human
Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest, 2014-07-01;124(8):3295-310. 2014-07-01 [PMID: 24983314] (Neutralization, Mouse)	Neutralization	Mouse
Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014-01-18;11(0):7. 2014-01-18 [PMID: 24438223] (Neutralization, Feline)	Neutralization	Feline
Allen M, Thomas G, Clark S, Dawoud M, Vallath S, Payne S, Gomm J, Dreger S, Dickinson S, Edwards D, Pennington C, Sestak I, Cuzick J, Marshall J, Hart I, Jones J Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of alphavbeta6 integrin in DCIS identifies high-risk patients and predicts recurrence. Clin Cancer Res, 2013-10-22;20(2):344-57. 2013-10-22 [PMID: 24150233] (Neutralization, Mouse)	Neutralization	Mouse
Kirsten Riches, Larissa Franklin, Azhar Maqbool, Michelle Peckham, Matthew Adams, Jacquelyn Bond et al. Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin alpha V beta 3 and RhoA/ROCK-mediated mechanisms☆ The International Journal of Biochemistry & Cell Biology 2013-08-01 [PMID: 23726972]
Michelle M. Miller, Jonathan E. Fogle, Peter Ross, Mary B. Tompkins Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency AIDS Research and Human Retroviruses 2013-04-01 [PMID: 23373523]
Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini F, Andreeff M, Kuratsu J, Lang F TGF-beta mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res, 2013-01-30;73(7):2333-44. 2013-01-30 [PMID: 23365134] (Western Blot, Human)	Western Blot	Human
Ellen J. Beswick, Iryna V. Pinchuk, Rachel B. Earley, David A. Schmitt, Victor E. Reyes Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection Infection and Immunity 2011-07-01 [PMID: 21482686]
Radoslaw Kowalewski, Andrzej Malkowski, Marek Gacko, Krzysztof Sobolewski Influence of thrombophlebitis on TGF-Î˛1 and its signaling pathway in the vein wall Folia Histochemica et Cytobiologica 2011-04-12 [PMID: 21478096]
Massam-Wu T, Chiu M, Choudhury R Assembly of fibrillin microfibrils governs extracellular deposition of latent TGF beta. J. Cell. Sci., 2010-08-10;123(0):3006-18. 8/10/2010 [PMID: 20699357]
Radoslaw Kowalewski, Andrzej Malkowski, Krzysztof Sobolewski, Marek Gacko Evaluation of transforming growth factor-beta signaling pathway in the wall of normal and varicose veins Pathobiology 2010-01-01 [PMID: 20185961]
Fogle JE, Mexas AM, Tompkins WA, Tompkins MB CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism. AIDS Res. Hum. Retroviruses, 2010-02-01;26(2):201-16. 2/1/2010 [PMID: 20156102]
Rai D, Kim SW, McKeller MR Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc. Natl. Acad. Sci. U.S.A., 2010-02-01;107(7):3111-6. 2010-02-01 [PMID: 20133617] (Neutralization, Human)	Neutralization	Human
Olav A. Gressner, Birgit Lahme, Monika Siluschek, Katharina Rehbein, Jens Herrmann, Ralf Weiskirchen et al. Activation of TGF-beta within cultured hepatocytes and in liver injury leads to intracrine signaling with expression of connective tissue growth factor Journal of Cellular and Molecular Medicine 2008-12-02 [PMID: 18266973]
Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res., 2008-01-15;68(2):561-70. 2008-01-15 [PMID: 18199553] (IHC-P, Human)	IHC-P	Human
Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, Wu L, Pankhurst G, Jiang L, Junankar S, Hunter M, Fairlie WD, Lee NJ, Enriquez RF, Baldock PA, Corey E, Apple FS, Murakami MM, Lin EJ, Wang C, During MJ, Sainsbury A, Herzog H, Breit SN Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat. Med., 2007-11-04;13(11):1333-40. 2007-11-04 [PMID: 17982462] (Neutralization, Mouse)	Neutralization	Mouse
Shazia S. Chaudhry, Stuart A. Cain, Amanda Morgan, Sarah L. Dallas, C. Adrian Shuttleworth, Cay M. Kielty Fibrillin-1 regulates the bioavailability of TGFbeta1 The Journal of Cell Biology 2007-01-29 [PMID: 17242066]
Hermitte F, Brunet de la Grange P, Belloc F, Praloran V, Ivanovic Z Very low O2 concentration (0.1%) favors G0 return of dividing CD34+ cells. Stem Cells, 2005-08-25;24(1):65-73. 2005-08-25 [PMID: 16123391] (Neutralization, Human)	Neutralization	Human
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Neutralization, Human)	Neutralization	Human
Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. 91, 2002-06-12;1590(1):1-15. 2002-06-12 [PMID: 12063164] (Neutralization, Rat)	Neutralization	Rat
Song QH, Klepeis VE, Trinkaus-Randall V TGF-beta1 regulates TGF-beta1 and FGF-2 mRNA expression during fibroblast wound healing. MP, Mol. Pathol., 2002-06-01;55(3):164-76. 2002-06-01 [PMID: 12032227] (IHC, Rabbit)	IHC	Rabbit
Show All 38 Publications. Collapse Publications.

Gene Symbol	TGFBR2
Uniprot	P37173.2()