Diabetes

By Hunter Martinez

Jamshed Arslan, Pharm D, PhD

By Jamshed Arslan, Pharm. D., PhD.

By Jamshed Arslan, Pharm. D., PhD.

By Jamshed Arslan Pharm.D.

Diabetes is a disease that impacts over 29 million people in the US (1). It is metabolic disorder that is the result of a high level or sugar or glucose in the blood. The three types of diabetes are Type 1, Type 2 and gestational diabetes, with Type 2 being the most common worldwide (2). The factors that contribute to a person getting Type 1 or Type 2 are largely unknown, but genetics, obesity and exercise have been linked to diabetes (3). Learn more about diabetes in our infographic below.

Inositol Requiring Enzyme 1 alpha (IRE1 alpha) is a transmembrane-RNase with an endoplasmic reticulum (ER) luminal sensor domain and cytosolic kinase and ribonuclease domains. IRE1 also plays a central role in the ER stress response (1).

Diabetic nephropathy (DN) is one of the leading complications resulting from chronic diabetes. It manifests as progressive renal failure caused by mesangial cell hyperplasia and fibrosis, and is one of the leading causes of terminal kidney disease (1). While the etiology is complex, an imbalance between pro- and anti-oxidant pathways in the kidney leading to an excess accumulation of reactive oxygen species (ROS) is believed to contribute in large part to the development of DN.

We at Novus Biologicals are one of the leading antibody suppliers for diabetes research. An aging population, and the increasing incidence of type 2 diabetes, makes it an area of increasing interest - especially as there is often a close link to cancer. Metabolic studies and diabetes research go hand-in-hand.