RIPK1/RIP1 Antibody - BSA Free

RIPK1 (Receptor Interacting Protein) is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell's decision to live or die. RIPK1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIPK1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIPK1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappaB activation. RIPK1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 7 applications: B/N, ICC/IF, IF/IHC, IHC, IHC-P, KD, WB.

Showing Publications 1 - 10 of 20. Show All 20 Publications. Collapse Publications.

Publications using NBP1-77077	Applications	Species
Shao R, Xie Q, Pan L et al. Necrostatin-1 attenuates Caspase-1-dependent pyroptosis induced by the RIPK1/ZBP1 pathway in ventilator-induced lung injury Cytokine 2022-09-01 [PMID: 35780712]
Liu K, Huang J, Liu J et al. Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells Cell death & disease 2022-06-02 [PMID: 35654783] (WB, Human)	WB	Human
Lorenzo N, Sanavia T, Rocco C et al. Necroptosis driving genes RIPK1, RIPK3, and MLKL-p are associated with intratumoral CD3+ and CD8+ T-cell density and predict prognosis in Hepatocellular Carcinoma Journal for ImmunoTherapy of Cancer 2022-01-01 [PMID: 35264437]
Kamiya M, Mizoguchi F, Kawahata K et al. Targeting necroptosis in muscle fibers ameliorates inflammatory myopathies Nature communications 2022-01-10 [PMID: 35013338] (ICC/IF, Mouse)	ICC/IF	Mouse
Pesce NA, Canovai A, Plastino F Et al. An imbalance in autophagy contributes to retinal damage in a rat model of oxygen-induced retinopathy Journal of cellular and molecular medicine 2021-10-08 [PMID: 34623024] (WB, ICC/IF, Rat)	WB, ICC/IF	Rat
Thadathil N, Nicklas EH, Mohammed S et al. Necroptosis increases with age in the brain and contributes to age-related neuroinflammation GeroScience 2021-10-01 [PMID: 34515928] (B/N)	B/N
Naseroleslami M, Niri NM, Akbarzade I et al. Simvastatin-loaded nano-niosomes confer cardioprotection against myocardial ischemia/reperfusion injury Drug delivery and translational research 2021-06-24 [PMID: 34165730]
Sharifi M, Nazarinia D, Ramezani F et al. Necroptosis and RhoA/ROCK pathways: molecular targets of Nesfatin-1 in cardioprotection against myocardial ischemia/reperfusion injury in a rat model Molecular biology reports 2021-03-23 [PMID: 33755849]
Zhao Y, Zhu X, Zhang L et al. Mesenchymal stem/stromal cells and their extracellular vesicle progeny decrease injury in post-stenotic swine kidney through different mechanisms Stem Cells Dev. 2020-07-12 [PMID: 32657229]
Li J, Shi J, Pan Y et al. Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression Sci Rep. 2019-11-22 [PMID: 31758083] (WB, Mouse)	WB	Mouse
Du XK, Ge WY, Jing R, Pan LH Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1 Int. Immunopharmacol. 2019-10-23 [PMID: 31655343] (KD, WB, Mouse)	KD, WB	Mouse
Bao Z, Fan L, Zhao L et al. Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis Front. Mol. Neurosci. 2019-09-19 [PMID: 31607859] (WB, Rat)	WB	Rat
Nilsson P, Loganathan K, Sekiguchi M et al. AB secretion and plaque formation depend on autophagy Cell Rep. 2013-10-17 [PMID: 24095740] (IHC-P, Mouse)	IHC-P	Mouse
Liu H, Deng X, Zhang L et al. Knockdown RIP-1 inhibits production of oxLDL-induced inflammatory cytokines and promotes ABCA1 expression in macrophages. Int J Clin Exp Med (WB, Mouse)	WB	Mouse
Wu Z, Fournel L, Stadler N et al. Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by Neurotensin antibody Cancer Lett. 2018-12-21 [PMID: 30583074] (IF/IHC, Human)	IF/IHC	Human
Ghardashi Afousi A, Gaeini A, Rakhshan K et al. Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury J Cell Commun Signal 2018-08-02 [PMID: 30073629] (WB, Rat)	WB	Rat
Tsuiji H, Inoue I, Takeuchi M et al. TDP-43 accelerates age-dependent degeneration of interneurons Sci Rep. 2017-11-02 [PMID: 29097807] (IHC-P, Mouse) Details: Novus RIPK1 IHC antibody was used to investigate necroptosis in TDP-43 Tg mice	IHC-P	Mouse
Miyake K, Ito J, Takahashi K et al. Single-cell transcriptomics identifies the differentiation trajectory from inflammatory monocytes to pro-resolving macrophages in skin allergy Research Square 2023-03-23 (IHC, Mouse)	IHC	Mouse
Al-Lamki RS, Lu W, Manalo P et al. Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis. Cell Death Dis 2016-06-30 [PMID: 27362805]
Miki Y, Akimoto J, Moritake K et al. Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells Lasers Med Sci. 2015-06-25 [PMID: 26109138] (WB, Human)	WB	Human
Show All 20 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	4 reviewed by: Verified Customer	IHC-P	Mouse	12/24/2014	View Summary Application Immunohistochemistry-Paraffin Sample Tested See PMID 24095740 Species Mouse

Array NBP1-77077

• RIPK1/RIP1 Antibodies
• RIPK1/RIP1 ELISA Kit
• RIPK1/RIP1 Lysate
• RIPK1/RIP1 Proteins