TRANCE/TNFSF11/RANK L Products

Description

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).

Bioinformatics

Entrez	117516 Rat 21943 Mouse 8600 Human
Uniprot	ENSP00000351347 Human NM_003701 Human NM_033012 Human NP_003692 Human NP_003692.1 Human NP_143026 Human O14788 Human O35235 Mouse
Product By Gene ID	8600
Alternate Names	CD254 antigen CD254 OPGLOPTB2 Osteoclast differentiation factor Osteoprotegerin ligand RANKLreceptor activator of nuclear factor kappa B ligand Receptor activator of nuclear factor kappa-B ligand sOdf TNF-related activation-induced cytokine TRANCEODFhRANKL2 tumor necrosis factor (ligand) superfamily, member 11 tumor necrosis factor ligand superfamily member 11

Research Areas for TRANCE/TNFSF11/RANK L

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Cancer

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The diverse functions of RANKL/TRANCE/TNFSF11 RANKL (also known as TNF-related activation-induced cytokine), or receptor activator of nuclear factor-?B ligand, was first discovered as a key player in the RANKL/RANK/OPG osteoclast formation pathway. Osteoclasts are large multinucleate cells t...    Read more.

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