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VIPR2/VPAC2 Antibody (476031) [Allophycocyanin]

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HEK293 human embryonic kidney cell line transfected with human VIP R2 and eGFP were stained with either (A) Mouse Anti-Human VIP R2 APC-conjugated Monoclonal Antibody (Catalog # FAB5416A) or (B) Mouse ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
476031
Clonality
Monoclonal
Host
Mouse
Conjugate
Allophycocyanin

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VIPR2/VPAC2 Antibody (476031) [Allophycocyanin] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human VIP R2
Glu24-Ile438
Accession # P41587
Specificity
Detects human VIP R2 in direct ELISAs.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
VIPR2
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Buffer
Supplied in a saline solution containing BSA and Sodium Azide.
Preservative
Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VIPR2/VPAC2 Antibody (476031) [Allophycocyanin]

  • FLJ16511
  • Helodermin-preferring VIP receptor
  • PACAP type III receptor
  • PACAPR3
  • PACAP-R3
  • PACAP-R-3
  • Pituitary adenylate cyclase-activating polypeptide type III receptor
  • vasoactive intestinal peptide receptor 2
  • vasoactive intestinal polypeptide receptor 2
  • VIP R2
  • VIP2R
  • VIPR2
  • VIP-R-2
  • VPAC2
  • VPCAP2R

Background

Human VIP R2 (Vasoactive Intestinal Polypeptide Receptor 2), also known as VPAC2 is a 60-70 kDa seven transmembrane glycoprotein receptor that belongs to the G protein coupled receptor 2 family of proteins. The mature chain contains in its first extracellular region a hormone receptor domain (aa 49‑114) which includes three N-linked glycosylation sites and a "cilia targeting signal" comprised of and Arg-Asp-Tyr-Arg sequence. Human VIP R2 shares 85% aa sequence identity with mouse and rat VIP R2. In the extracellular domains, human VIP R2 shares 88% and 31% aa sequence identity with mouse VIP R2 and human VIP R1, respectively. VIP R2 is expressed predominantly in skeletal muscle, CD4+ T cells, smooth muscle cells, plasmacytoid dendritic cells, hepatic progenitor cells, monocytes, synoviocytes and select neurons. VIP R1 and VIP R2 bind VIP with equal affinity, but the two receptors are not redundant. VIP R1 interacts with RAMPs; VIP R2 does not. In the dentate gyrus, VIP R1 drives stem cells into a granule cell phenotype while VIP R2 maintains a Nestin+ phenotype.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol VIPR2
Uniprot