TRAILR1/TNFRSF10A Antibody (32A1380) - Azide and BSA Free

Cells undergo programmed cell death (Apoptosis) in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense (1). Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A death domain containing receptor has been identified and designated DR4 (for death receptor 4) (2). The ligand for this death receptor has been identified and termed TRAIL (3,4), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAIL-R1) (5). DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: FLOW, Flow - CS, Flow Cytometry Control.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NBP2-27350	Applications	Species
Park S, Cho DH, Andera L et al. Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins. Mol Cell Biochem 2013-11-01 [PMID: 23846485]
Jane EP, Premkumar DR, Pollack IF. Bortezomib sensitizes malignant human glioma cells to TRAIL, mediated by inhibition of the NF-{kappa}B signaling pathway. Mol Cancer Ther. 2011-01-01 [PMID: 21220502] Details: DR4 (IMG-141A) and DR5/TRAILR2 (IMG-120A). WB: Various human glioma cell lines treated with TRAIL: LN18, U87, LNZ308, and U373, Fig 2B & 2C.
Lin YD, Chen S, Yue P et al. CAAT/enhancer binding protein homologous protein-dependent death receptor 5 induction is a major component of SHetA2-induced apoptosis in lung cancer cells. Cancer Res. 2008-07-01 [PMID: 18593935] Details: Antibodies cited: [WB ( human non-small cell lung cancer cell lines)]: 1. Anti-caspase-3 (IMG-144A): Figs. 1A,B; 5A. 2. DR4 (NT) TRAIL-R1 (IMG-141A): Figs. 3A.
Le Poole IC, ElMasri WM, Denman CJ et al. Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells. Cancer Immunol Immunother. 2008-06-01 [PMID: 18004565] (Flow - CS, Human) Details: Flow (cell surface), human dendritic cells and langerhans cells, Fig. 4A.	Flow - CS	Human
Tsurushima H, Yuan X, Dillehay LE et al. Radioresponsive tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene therapy for malignant brain tumors. Cancer Gene Ther. 2007-08-01 [PMID: 17541421] (Flow Cytometry Control, Human) Details: DR4 NT TRAIL-R1 (IMG-141A). Flow (intracellular): Human malignant glioma (U251 & U87) cell lines exposed to varying times of radiation, Fig 4.	Flow Cytometry Control	Human
Kroll TM, Bommiasamy H, Boissy RE et al. 4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. J Invest Dermatol. 2005-04-01 [PMID: 15816839] (FLOW)	FLOW
Ren YG, Wagner KW, Knee DA et al. Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle. Mol Biol Cell. 2004-11-01 [PMID: 15356269]
Liu X, Yue P, Khuri FR, Sun SY. p53 upregulates death receptor 4 expression through an intronic p53 binding site. Cancer Res. 2004-08-01 [PMID: 15289308]
Chen X, Kandasamy K, Srivastava RK. Differential roles of RelA (p65) and c-Rel subunits of nuclear factor kappa B in tumor necrosis factor-related apoptosis-inducing ligand signaling. Cancer Res. 2003-03-01 [PMID: 12615723]
Guan B, Yue P, Lotan R, Sun SY. Evidence that the human death receptor 4 is regulated by activator protein 1. Oncogene. 2002-05-09 [PMID: 12082627]
Bretz JD, Mezosi E, Giordano TJ et al. Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells. Cell Death Differ. 2002-03-01 [PMID: 11859410]
Show All 11 Publications. Collapse Publications.

Array NBP2-27350

• TRAILR1/TNFRSF10A Antibodies
• TRAILR1/TNFRSF10A Antibody Pair
• TRAILR1/TNFRSF10A ELISA Kit
• TRAILR1/TNFRSF10A Proteins
• TRAILR1/TNFRSF10A Proteins and Enzymes