Thrombomodulin/BDCA-3 Antibody (6C8.2F9) - Azide and BSA Free

Thrombomodulin (THBD/CD141) is a transmembrane glycoprotein which acts as a physiological anticoagulant and its anticoagulation activities are accomplished by transforming thrombin from a pro-coagulant to an anticoagulant, directly inhibiting its clotting /cell activation potential. THBD generates a 1:1 stoichiometric complex with thrombin resulting in the activation of protein C which then scissions the activated coagulation cofactors (factor Va and factor VIIIa) and thereby reducing the amount of thrombin generated. THBD is expressed mainly by endothelial cells, however, its presence on the surface of other cell types such as epithelial cells, mesothelial cells, immune cells, osteoblasts and islet cells has also been documented. Besides its critical role in the regulation of coagulation process, THBD implicates in inflammation, fibrinolysis and cellular proliferation also. It provides protection against endothelial injury as well as microvascular thrombosis and it acts as a negative regulator of the complement system. Mutations in THBD gene have been linked to disorders such as Thrombophilia due to thrombomodulin defect (THPH12) and atypical haemolytic uraemic syndrome (aHUS)/ Hemolytic uremic syndrome atypical 6 (AHUS6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP2-80979

• Thrombomodulin/BDCA-3 Antibodies
• Thrombomodulin/BDCA-3 ELISA Kits
• Thrombomodulin/BDCA-3 Protein
• Thrombomodulin/BDCA-3 ELISAs
• Thrombomodulin/BDCA-3 Proteins and Enzymes