STAT3 Antibody

STATs (signal transducers and activators of transcription) were originally discovered as two proteins (STAT1 and STAT2) which were involved in interferon alpha (IFN alpha) and IFN gamma signal transduction. Since then, several additional STAT proteins have been identified (STAT3, 4, 5a, 5b, and 6). STATs undergo tyrosine phosphorylation in response to growth factor or cytokine signaling. This phosphorylation results in dimerization and translocation of STAT proteins to the nucleus. In some cases this process is mediated by JAK Kinases (Janus Kinases 1, 2, and 3). For maximum activation of these proteins, phosphorylation at specific tyrosine and serine residues may be required in STAT1 alpha, 3, 4, and 5. Specific functions of the various members of the STAT family are poorly understood. STAT3 has been shown to be activated by IFN alpha but not IFN beta. The transcription factors associated with STAT3 are cJun and cyclic AMP responsive enhancer binding protein (CREB). Deletion of the STAT3 gene in knock-out mice was lethal at the early embryonic stage. STAT1 and STAT2 are induced by IFN alpha and forn1 a heterodimer which is part of the ISGF transcription factor complex. The STAT3 protein is expressed in most cell types and is activated by multiple cytokines and growth factors including: IFNa, IL10, IL6, IL11, IL12, IL2, EGF, among others. STAT3 beta appears to be activated by both EGF and IL6, but STAT3 alpha is only activated by EGF. STAT3 binds to DNA as either a homodimer or as a heterodimer with STAT1. STAT3 interacts with the APRE acute phase response element) and SIE (csis inducible element). STAT4, predominantly expressed in testis and myeloid cells, is activated by ILl2. STAT5 is activated by prolactin and IL3. STAT6 participates in signaling pathways mediated by IL4.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using NB100-799	Applications	Species
Kannan A, Cuartas J, Gangwani P et al. Mutation in senataxin alters the mechanism of R-loop resolution in amyotrophic lateral sclerosis 4 Brain : a journal of neurology 2022-01-19 [PMID: 35045161]
Martha Habibi, Panagiotis K. Karyofyllis, Aggeliki Nikolakopoulou, Panagiotis Papagiannis, Pantelis Karaiskos, Alexandros G. Georgakilas, Vasiliki I. Hatzi, Ioannis Malakos, Nikolaos Kollaros, Irene Mastorakou, Vassilis Voudris, Georgia I. Terzoudi The Use of Genotoxicity Endpoints as Biomarkers of Low Dose Radiation Exposure in Interventional Cardiology Frontiers in Public Health 2021-07-23 [PMID: 34368064]
Torres-Querol C, Torres P, Vidal N Et al. Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype Scientific reports 2021-08-03 [PMID: 34344977]
Yoshioka N, Tanaka M, Ochi K et al. The sodium-glucose cotransporter-2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021-05-21 [PMID: 34029949]
Russo I, Carrizzo A, Bochicchio S et al. siRNA Delivery for Control of Cyclin D1 and E2F1 Expression in Crohn's Disease. Transl Med UniSa 2017-07-01 [PMID: 30050877]
A Kannan, K Bhatia, D Branzei, L Gangwani Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy Nucleic Acids Res., 2018-09-19;0(0):. 2018-09-19 [PMID: 30010942]
Itoh M, Suganami T, Kato H et al. CD11c+ resident macrophages drive hepatocyte death-triggered liver fibrosis in a murine model of nonalcoholic steatohepatitis. JCI Insight. 2017-11-16 [PMID: 29202448]
Wang BY, Liao ML, Hong GC et al. Near-Infrared-Triggered Photodynamic Therapy toward Breast Cancer Cells Using Dendrimer-Functionalized Upconversion Nanoparticles Nanomaterials (Basel) 2017-09-11 [PMID: 28892021]
Duka T, Collins Z, Anderson SM et al. Divergent lactate dehydrogenase isoenzyme profile in cellular compartments of primate forebrain structures Molecular and Cellular Neuroscience 2017-07-01 [PMID: 28461219]
Son YO, Pratheeshkumar P, Divya SP et al. Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells. J. Biol. Chem. 2017-03-22 [PMID: 28330870]
Nikitaki Z, Nikolov V, Mavragani IV et al. Measurement of complex DNA damage induction and repair in human cellular systems after exposure to ionizing radiations of varying linear energy transfer (LET). Free Radic Res 2016-11-01 [PMID: 27593437]
Magimaidas A, Madireddi P, Maifrede S et al. Gadd45b deficiency promotes premature senescence and skin aging. Oncotarget. 2016-05-10 [PMID: 27105496]
Oaks AW, Frankfurt M, Finkelstein DI, Sidhu A. Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function PLoS One 2013-01-01 [PMID: 23560093]
Jia R, Pan Q, Ding S et al. The N-terminal region of IFITM3 modulates its antiviral activity through regulating IFITM3 cellular localization. J Virol 2012-10-10 [PMID: 23055554]
Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, Sonenberg N, Roberge M. Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem;287(21):17530-45. 2012-05-18 [PMID: 22474287]
Velarde MC, Flynn JM, Day NU et al. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging. 2012-01-20 [PMID: 22278880]
Guez-Barber D, Fanous S, Harvey BK et al. FACS purification of immunolabeled cell types from adult rat brain. J Neurosci Methods. 2011-09-03 [PMID: 21911005]
McIntosh AL, Storey SM, Atshaves BP. Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity. Lipids 2010-06-01 [PMID: 20473576]
Bromberg JF, Wrzeszczynska MH, Devgan G et al. Stat3 as an oncogene. Cell 1999-08-06 [PMID: 10458605]
Show All 19 Publications. Collapse Publications.

Array NB100-799

• STAT3 Antibodies
• STAT3 Lysates
• STAT3 Proteins
• STAT3 ELISA