Sonic Hedgehog/Shh Antibody (5H4)

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 5 applications: FLOW, ICC/IF, IF/IHC, IHC-P, WB.

Showing Publications 1 - 6 of 6.

Publications using NBP2-22126	Applications	Species
Vidal MTA Dos Santos JN. Estudo imunoistoquimico de componentes da via Sonic Hedgehog, STAT3 e MCM3 em tumores de glandula salivar. Thesis. 2015-01-01 (IHC-P, Human)	IHC-P	Human
Ferreira Mendes, J M, de Faro Valverde, L Et al. Effects of IGF-1 on Proliferation, Angiogenesis, Tumor Stem Cell Populations and Activation of AKT and Hedgehog Pathways in Oral Squamous Cell Carcinoma. Int J Mol Sci 2020-09-05 [PMID: 32899449] (WB, Human)	WB	Human
Singh SK, Gordetsky JB, Bae S et al. Selective Targeting of the Hedgehog Signaling Pathway by PBM Nanoparticles in Docetaxel-Resistant Prostate Cancer Cells 2020-08-27 [PMID: 32867229] (IF/IHC, ICC/IF, FLOW, Human)	IF/IHC, ICC/IF, FLOW	Human
Bacelar Sacramento de AraUjo T, de Oliveira Siquara da Rocha L, Torres Andion Vidal M et al. GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells International journal of molecular sciences 2020-08-24 [PMID: 32846867] (WB, ICC/IF, Human)	WB, ICC/IF	Human
Vidal MT, Lourenco SV, Soares FA et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumour Biol. 2016-01-21 [PMID: 26790448] (IHC-P, Human)	IHC-P	Human
Valverde LF, Pereira TA, Dias RB et al. Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. Tumour Biol. 2016-01-15 [PMID: 26768620] (IHC-P, Human)	IHC-P	Human

Array NBP2-22126

• Sonic Hedgehog/Shh Antibodies
• Sonic Hedgehog/Shh ELISA Kits
• Sonic Hedgehog/Shh Lysate
• Sonic Hedgehog/Shh Proteins
• Sonic Hedgehog/Shh Proteins and Enzymes
• Sonic Hedgehog/Shh ELISAs