SOD2/Mn-SOD Antibody

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2- to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space(8). SOD3 can also be distinguished by its heparin-binding capacity (1).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-Fr.

Showing Publications 1 - 5 of 5.

Publications using NB100-1969	Applications	Species
Lakhani R, Vogel KR, Till A et al. Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition. EMBO Mol Med 2014-02-28 [PMID: 24578415] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Kalash R, Epperly MW, Goff J et al. Amelioration of Radiation-Induced Pulmonary Fibrosis by a Water-Soluble Bifunctional Sulfoxide Radiation Mitigator (MMS350). Radiat Res. 2013-11-01 [PMID: 24125487]
Epperly MW, Chaillet JR, Kalash R et al. Conditional Radioresistance of tet-Inducible Manganese Superoxide Dismutase Bone Marrow Stromal Cell Lines. Radiat Res 2013-08-01 [PMID: 23862693]
Dumont M, Stack C, Elipenahli C et al. Behavioral deficit, oxidative stress, and mitochondrial dysfunction precede tau pathology in P301S transgenic mice. FASEB J. 2011-08-08 [PMID: 21825035]
Lee DW, Rajagopalan S, Siddiq A et al. Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity: MODEL FOR THE POTENTIAL INVOLVEMENT OF THE HYPOXIA-INDUCIBLE FACTOR PATHWAY IN PARKINSON DISEASE. J Biol Chem;284(42):29065-29076. 2009-01-01 [PMID: 19679656]

Array NB100-1969

• SOD2/Mn-SOD Antibodies
• SOD2/Mn-SOD Lysates
• SOD2/Mn-SOD Proteins
• SOD2/Mn-SOD ELISA