I am looking for an ovine antibody for bFGF and PDGF-AB and ELISA Kits for both. It is for a research work on meniscus healing in sheep. Do you have anything suitable? How is the homology with sheep? Is it ever tested and/or published in papers?

Name: Recombinant Rat FGF basic/FGF2/bFGF Protein
Brand: Novus Biologicals
SKU: 3339-FB
Price: 318 USD

Unfortunately, most of the products you are interested in have not yet been tested in sheep, but this should not be a problem, due to sequence homology, and our Innovators Reward Program. In terms of an antibody for bFGF, also called FGF-2, we have several antibodies that are validated to detect the bovine protein, which is almost identical to that from sheep (99% homology). We only have FGF2 ELISA kits that have been tested with human or mouse. Mouse FGF-2 has 94% homology with sheep; human has 98% homology for most of its sequence, but also has an additional stretch of amino acids that is not present in the sheep protein. I therefore think that the mouse kit would be most suitable, just in case the human kit targets the region of the human protein not present in mouse. We sell antibodies to PDGF-A or PDGF-B rather than PDGF-AB. We don't have any PDGF-A antibodies that have been tested in sheep but there are several options you may find of interest. There isn't a sheep PDGFA sequence in UniProt, so I can't comment on how similar it is to the PDGFA from other species. Nevertheless, our NBP1-52533 PDGFB antibody has been shown to work in sheep. We sell two PDGF-AB ELISA kits , but these are for human and rat. I'm not sure how well these would work with sheep. Note that if you test a product with a species (or application) that it has not yet been validated in, you are eligible for our Innovator's Reward: Novus would provide you a 50% refund on the purchased product as well as a 50% discount on a future product of equal or lesser value. You would email innovators@novusbio.com to apply for your award, and we

Recombinant Rat FGF basic/FGF2/bFGF Protein (3339-FB): Novus Biologicals

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	RtSpecies Glossary
Applications	Bioactivity

Details of Functionality	Measured in a cell proliferation assay using NR6R‑3T3 mouse fibroblast cells. Rizzino, A. et al. (1988) Cancer Res. 48:4266; Thomas, K. et al. (1987) Methods Enzymol. 147:120. The ED₅₀ for this effect is 0.3-1.8 ng/mL.
Source	E. coli-derived rat FGF basic/FGF2/bFGF protein Ala11-Ser154
Accession #	P13109
N-terminal Sequence	Ala11
Protein/Peptide Type	Recombinant Proteins
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note	<0.01 EU per 1 μg of the protein by the LAL method.

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in MOPS, Na₂SO₄, EDTA and DTT with BSA as a carrier protein.
Purity	>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Publications using 3339-FB	Applications	Species
Wu, Y;Sun, J;Lin, Q;Wang, D;Hai, J; Sustained release of vascular endothelial growth factor A and basic fibroblast growth factor from nanofiber membranes reduces oxygen/glucose deprivation-induced injury to neurovascular units Neural regeneration research 2024-04-01 [PMID: 37843225] (Bioassay)	Bioassay
SY Park, JS Han Neuroprotective Effect of Bcl-2 on Lipopolysaccharide-Induced Neuroinflammation in Cortical Neural Stem Cells International Journal of Molecular Sciences, 2022-06-07;23(12):. 2022-06-07 [PMID: 35742844] (Bioassay, Rat)	Bioassay	Rat
X Wang, Z Zhang, Z Zhu, Z Liang, X Zuo, C Ju, Z Song, X Li, X Hu, Z Wang Photobiomodulation Promotes Repair Following Spinal Cord Injury by Regulating the Transformation of A1/A2 Reactive Astrocytes Frontiers in Neuroscience, 2021-11-02;15(0):768262. 2021-11-02 [PMID: 34795557] (Bioassay, Rat)	Bioassay	Rat
M Furuhata, T Takayama, T Yamamoto, Y Ozawa, M Senoo, M Ozaki, S Yamano, S Sato Real-time assessment of guided bone regeneration in critical size mandibular bone defects in rats using collagen membranes with adjunct fibroblast growth factor-2 Journal of dental sciences, 2021-04-03;16(4):1170-1181. 2021-04-03 [PMID: 34484585] (In Vivo, Rat)	In Vivo	Rat
T Shimizu, H Murakoshi, H Matsumoto, K Ichino, A Hattori, S Ueno, A Ishida, N Tajiri, H Hida Tension Sensor Based on Fluorescence Resonance Energy Transfer Reveals Fiber Diameter-Dependent Mechanical Factors During Myelination Frontiers in Cellular Neuroscience, 2021-08-02;15(0):685044. 2021-08-02 [PMID: 34408628] (Bioassay, Rat)	Bioassay	Rat
S Mukherjee, MA Cabrera, NI Boyadjieva, G Berger, B Rousseau, DK Sarkar Alcohol increases exosome release from microglia to promote complement C1q induced cellular death of proopiomelanocortin neurons in the hypothalamus in a rat model of fetal alcohol spectrum disorders J. Neurosci., 2020-09-04;0(0):. 2020-09-04 [PMID: 32887744] (Bioassay, Rat)	Bioassay	Rat
B Fan, W Pan, X Wang, M Wei, A He, A Zhao, M Chopp, ZG Zhang, XS Liu Long noncoding RNA mediates stroke-induced neurogenesis Stem Cells, 2020-05-02;0(0):. 2020-05-02 [PMID: 32346940] (Bioassay, Rat)	Bioassay	Rat
M Nakamura, H Nishida, K Yoshizaki, H Akiyoshi, S Hatoya, K Sugiura, T Inaba Canine mesenchymal stromal cell-conditioned medium promotes survival and neurite outgrowth of neural stem cells J. Vet. Med. Sci., 2020-04-06;0(0):. 2020-04-06 [PMID: 32249241] (Rat)		Rat
AE Zanno, MA Romer, L Fox, T Golden, L Jaeckle-Sa, RA Simmons, JB Grinspan Reducing Th2 inflammation through neutralizing IL-4 antibody rescues myelination in IUGR rat brain J Neurodev Disord, 2019-12-16;11(1):34. 2019-12-16 [PMID: 31839002] (Bioassay, Rat)	Bioassay	Rat
X Liang, Q Mao, D Huang, J Tang, J Zheng Overexpression of cortistatin alleviates oxygen/glucose-deprivation-induced ER stress and prompts neural stem cell proliferation via SSTR2 Exp. Mol. Pathol., 2019-12-03;0(0):104351. 2019-12-03 [PMID: 31809712] (Bioassay, Rat)	Bioassay	Rat
HH Park, MH Han, H Choi, YJ Lee, JM Kim, JH Cheong, JI Ryu, KY Lee, SH Koh Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate Sci Rep, 2019-10-31;9(1):15717. 2019-10-31 [PMID: 31673096] (Cell Culture, Rat)	Cell Culture	Rat
EH Lee, SM Kim, CH Kim, SH Pagire, HS Pagire, HY Chung, JH Ahn, CH Park Dopamine neuron induction and the neuroprotective effects of thyroid hormone derivatives Sci Rep, 2019-09-20;9(1):13659. 2019-09-20 [PMID: 31541140] (Bioassay, Rat)	Bioassay	Rat
SR Sankavaram, R Hakim, R Covacu, A Frostell, S Neumann, M Svensson, L Brundin Adult Neural Progenitor Cells Transplanted into Spinal Cord Injury Differentiate into Oligodendrocytes, Enhance Myelination, and Contribute to Recovery Stem Cell Reports, 2019-04-25;0(0):. 2019-04-25 [PMID: 31031190] (Bioassay, Rat)	Bioassay	Rat
W Zhang, X Li, S Sun, X Zhang Implantation of engineered conduction tissue in the rat heart Mol Med Rep, 2019-02-05;0(0):. 2019-02-05 [PMID: 30720107] (Bioassay, Rat)	Bioassay	Rat
X Sun, Y Zhu, HY Yin, ZY Guo, F Xu, B Xiao, WL Jiang, WM Guo, HY Meng, SB Lu, Y Wang, J Peng Differentiation of adipose-derived stem cells into Schwann cell-like cells through intermittent induction: potential advantage of cellular transient memory function Stem Cell Res Ther, 2018-05-11;9(1):133. 2018-05-11 [PMID: 29751848] (Bioassay, Rat)	Bioassay	Rat
JW Robinson, JR Egbert, J Davydova, H Schmidt, LA Jaffe, LR Potter Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B Cell. Signal., 2017-09-28;40(0):222-229. 2017-09-28 [PMID: 28964968] (Bioassay, Rat)	Bioassay	Rat
JD Karkera, G Martinez C, K Bell, D Gaffney, JC Portale, A Santiago-W, C Moy, P King, M Sharp, R Bahleda, FR Luo, JD Alvarez, MV Lorenzi, SJ Platero Oncogenic Characterization and Pharmacologic Sensitivity of Activating Fibroblast Growth Factor Receptor (FGFR) Genetic Alterations to the Selective FGFR Inhibitor Erdafitinib Mol. Cancer Ther., 2017-04-17;0(0):. 2017-04-17 [PMID: 28416604] (Bioassay, Rat)	Bioassay	Rat
D Wang, A Wang, F Wu, X Qiu, Y Li, J Chu, WC Huang, K Xu, X Gong, S Li Sox10(+) adult stem cells contribute to biomaterial encapsulation and microvascularization Sci Rep, 2017-01-10;7(0):40295. 2017-01-10 [PMID: 28071739] (Bioassay, Rat)	Bioassay	Rat
M Vitacolonn In-vivo quantification of the revascularization of a human acellular dermis seeded with EPCs and MSCs in co-culture with fibroblasts and pericytes in the dorsal chamber model in pre-irradiated tissue Cell Tissue Bank, 2016-12-21;0(0):. 2016-12-21 [PMID: 28004288] (Bioassay, Rat)	Bioassay	Rat
Joong-Soo Han Hippocalcin Is Required for Astrocytic Differentiation through Activation of Stat3 in Hippocampal Neural Precursor Cells Front Mol Neurosci, 2016-10-28;9(0):110. 2016-10-28 [PMID: 27840601] (Bioassay, Rat)	Bioassay	Rat
Angiogenic microspheres promote neural regeneration and motor function recovery after spinal cord injury in rats Sci Rep, 2016-09-19;6(0):33428. 2016-09-19 [PMID: 27641997] (In Vivo, Rat)	In Vivo	Rat
He X, Kim M, Kim S, Yi S, Rhee Y, Kim T, Lee E, Park C, Dixit S, Harrison F, Lee S Vitamin C facilitates dopamine neuron differentiation in fetal midbrain through TET1- and JMJD3-dependent epigenetic control manner. Stem Cells, 2015-04-01;33(0):1320. 2015-04-01 [PMID: 25535150] (Bioassay, Rat)	Bioassay	Rat
Xu W, Sun Y, Zhang J, Xu K, Pan L, He L, Song Y, Njunge L, Xu Z, Chiang M, Sung K, Chuong C, Yang L Perivascular-derived stem cells with neural crest characteristics are involved in tendon repair. Stem Cells Dev, 2015-01-19;24(7):857-68. 2015-01-19 [PMID: 25381682] (Bioassay, Rat)	Bioassay	Rat
Covacu R, Perez Estrada C, Arvidsson L, Svensson M, Brundin L Change of fate commitment in adult neural progenitor cells subjected to chronic inflammation. J Neurosci, 2014-08-27;34(35):11571-82. 2014-08-27 [PMID: 25164655] (Bioassay, Rat)	Bioassay	Rat
Romariz S, Paiva D, Valente M, Barnabe G, Frussa-Filho R, Barbosa-Silva R, Calcagnotto M, Longo B Long-lasting anxiolytic effect of neural precursor cells freshly prepared but not neurosphere-derived cell transplantation in newborn rats. BMC Neurosci, 2014-08-02;15(0):94. 2014-08-02 [PMID: 25086450] (Bioassay, Rat)	Bioassay	Rat
Kandasamy M, Lehner B, Kraus S, Sander P, Marschallinger J, Rivera F, Trumbach D, Ueberham U, Reitsamer H, Strauss O, Bogdahn U, Couillard-Despres S, Aigner L TGF-beta signalling in the adult neurogenic niche promotes stem cell quiescence as well as generation of new neurons. J Cell Mol Med, 2014-04-30;18(7):1444-59. 2014-04-30 [PMID: 24779367] (Bioassay, Rat)	Bioassay	Rat
Reed , Daniel M, Foldes , Gabor, Gatheral , Timothy, Paschalaki , Koralia, Lendvai , Zsuzsann, Bagyura , Zsolt, Nemeth , Tamas, Skopal , Judit, Merkely , Bela, Telcian , Aurica G, Gogsadze , Leila, Edwards , Michael, Gough , Peter J, Bertin , John, Johnston , Sebastia, Harding , Sian E, Mitchell , Jane A Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors. PLoS ONE, 2014-04-01;9(4):e91119. 2014-04-01 [PMID: 24690886] (In Vivo, Rat)	In Vivo	Rat
Matsushita , Masaki, Kitoh , Hiroshi, Ohkawara , Bisei, Mishima , Kenichi, Kaneko , Hiroshi, Ito , Mikako, Masuda , Akio, Ishiguro , Naoki, Ohno , Kinji Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia. PLoS ONE, 2013-12-04;8(12):e81569. 2013-12-04 [PMID: 24324705] (Bioassay, Rat)	Bioassay	Rat
Dawes L, Sugiyama Y, Lovicu F, Harris C, Shelley E, McAvoy J Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Dev Biol, 2013-11-08;385(2):291-303. 2013-11-08 [PMID: 24211762] (Bioassay, Rat)	Bioassay	Rat
Qi , Lin, Li , Ning, Huang , Rong, Song , Qin, Wang , Long, Zhang , Qi, Su , Ruigong, Kong , Tao, Tang , Minglian, Cheng , Guosheng The effects of topographical patterns and sizes on neural stem cell behavior. PLoS ONE, 2013-03-18;8(3):e59022. 2013-03-18 [PMID: 23527077] (Bioassay, Rat)	Bioassay	Rat
Dawes L, Sugiyama Y, Tanedo A, Lovicu F, McAvoy J Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci, 2013-03-01;54(3):1582-90. 2013-03-01 [PMID: 23385791] (Bioassay, Rat)	Bioassay	Rat
Asumda FZ, Chase PB Age-related changes in rat bone-marrow mesenchymal stem cell plasticity. BMC Cell Biol., 2011-10-12;12(0):44. 2011-10-12 [PMID: 21992089] (Bioassay, Rat)	Bioassay	Rat
Krejci P, Prochazkova J, Bryja V, Jelinkova P, Pejchalova K, Kozubik A, Thompson LM, Wilcox WR Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes. Cell. Signal., 2008-10-12;21(1):151-60. 2008-10-12 [PMID: 18950705] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin. Stem Cells, 2007-09-27;26(1):163-72. 2007-09-27 [PMID: 17901404] (Bioassay, Rat)	Bioassay	Rat
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Recombinant Rat FGF basic/FGF2/bFGF Protein

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Carrier Free 3339-FB-025/CF