Recombinant Mouse IL-18/IL-1F4 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-18 (IL-18) is a proinflammatory cytokine in the IL-1 family that exerts distinct immune effects depending on the local cytokine environment. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. The precursor is activated intracellularly by Caspase-1 mediated proteolysis to release the 17 kDa mature cytokine. The precursor can also be released by necrotic cells for extracellular cleavage by multiple proteases.
IL-18 activation is induced by infection or tissue damage and contributes to disease pathology in chronic inflammation (1-3). IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex (4, 5). Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs (6). In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8⁺ T cells and NK cells (7, 8). In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4⁺ T cells and basophils (9, 10). In the presence of IL-1 beta or IL-23, IL-18 induces the antigen-independent production of IL-17 by gamma δ T cells and CD4⁺ T cells (11). IL-18 also promotes myeloid dendritic cell maturation and triggers neutrophil respiratory burst (12, 13). In cancer, IL-18 exhibits diverse activities including enhancing anti-tumor immunity, inhibiting or promoting angiogenesis, and promoting tumor cell metastasis (14). Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively (15).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), ELISA Standard, In Vivo.

Showing Publications 1 - 10 of 35. Show All 35 Publications. Collapse Publications.

Publications using B002-5	Applications	Species
J Yu, H Zhu, S Taheri, W Mondy, L Bonilha, GS Magwood, D Lackland, RJ Adams, MS Kindy Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia J. Neurosci., 2019-10-14;0(0):. 2019-10-14 [PMID: 31611307] (ELISA Standard, Mouse)	ELISA Standard	Mouse
RP Semper, M Vieth, M Gerhard, R Mejías-Luq Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses J. Immunol., 2019-09-11;0(0):. 2019-09-11 [PMID: 31511355] (Bioassay, Mouse)	Bioassay	Mouse
VC Lam, L Folkersen, OA Aguilar, LL Lanier KLF12 Regulates Mouse NK Cell Proliferation J. Immunol., 2019-07-12;0(0):. 2019-07-12 [PMID: 31300511] (Bioassay, Mouse)	Bioassay	Mouse
OE Weizman, E Song, NM Adams, AD Hildreth, L Riggan, C Krishna, OA Aguilar, CS Leslie, JR Carlyle, JC Sun, TE O'Sullivan Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Nat. Immunol., 2019-07-01;0(0):. 2019-07-01 [PMID: 31263280] (Bioassay, Mouse)	Bioassay	Mouse
TA Mace, MB Ware, SA King, S Loftus, MR Farren, E McMichael, S Scoville, C Geraghty, G Young, WE Carson, SK Clinton, GB Lesinski Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function Sci Rep, 2019-03-25;9(1):5068. 2019-03-25 [PMID: 30911044] (In Vivo, Mouse)	In Vivo	Mouse
P Kumar, K Rajasekara, A Nanbakhsh, J Gorski, MS Thakar, S Malarkanna IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection Sci Rep, 2019-03-21;9(1):4984. 2019-03-21 [PMID: 30899058] (Bioassay, Mouse)	Bioassay	Mouse
R Alhallaf, Z Agha, CM Miller, AAB Robertson, J Sotillo, J Croese, MA Cooper, SL Masters, A Kupz, NC Smith, A Loukas, PR Giacomin The NLRP3 Inflammasome Suppresses Protective Immunity to Gastrointestinal Helminth Infection Cell Rep, 2018-04-24;23(4):1085-1098. 2018-04-24 [PMID: 29694887] (In Vivo, Mouse)	In Vivo	Mouse
T Nabekura, Z Chen, C Schroeder, T Park, E Vivier, LL Lanier, D Liu Crk Adaptor Proteins Regulate NK Cell Expansion and Differentiation during Mouse Cytomegalovirus Infection J. Immunol., 2018-04-04;0(0):. 2018-04-04 [PMID: 29618525] (Bioassay, Mouse)	Bioassay	Mouse
Z Wang, Z Liu, L Wang, J Wang, L Chen, H Xie, H Zhang, S He Altered expression of IL-18 binding protein and IL-18 receptor in basophils and mast cells of asthma patients Scand. J. Immunol., 2018-04-10;0(0):. 2018-04-10 [PMID: 29505668] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
GM Castillo, A Nishimoto-, CC Jones, KK Kabirov, A Zakharov, AV Lyubimov Protected graft copolymer-formulated fibroblast growth factors mitigate the lethality of partial body irradiation injury PLoS ONE, 2017-02-16;12(2):e0171703. 2017-02-16 [PMID: 28207794] (ELISA (Standard), Mouse)	ELISA (Standard)	Mouse
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence Nature, 2016-07-13;535(7612):440-3. 2016-07-13 [PMID: 27409807] (Bioassay, Mouse)	Bioassay	Mouse
Seregin S, Chen G, Laouar Y Dissecting CD8+ NKT Cell Responses to Listeria Infection Reveals a Component of Innate Resistance. J Immunol, 2015-06-26;195(3):1112-20. 2015-06-26 [PMID: 26116500] (Bioassay, Mouse)	Bioassay	Mouse
Nabekura T, Girard J, Lanier L IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection. J Immunol, 2015-04-29;194(12):5948-52. 2015-04-29 [PMID: 25926677] (Bioassay, Mouse)	Bioassay	Mouse
Souza-Fonseca-Guimaraes F, Young A, Mittal D, Martinet L, Bruedigam C, Takeda K, Andoniou C, Degli-Esposti M, Hill G, Smyth M NK cells require IL-28R for optimal in vivo activity. Proc Natl Acad Sci U S A, 2015-04-21;112(18):E2376-84. 2015-04-21 [PMID: 25901316] (Bioassay, Mouse)	Bioassay	Mouse
Gandhapudi S, Tan C, Marino J, Taylor A, Pack C, Gaikwad J, Van De Wiele C, Wren J, Teague T IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol, 2015-03-16;194(8):3820-8. 2015-03-16 [PMID: 25780034] (Bioassay, Mouse)	Bioassay	Mouse
Chen P, Aguilar O, Rahim M, Allan D, Fine J, Kirkham C, Ma J, Tanaka M, Tu M, Wight A, Kartsogiannis V, Gillespie M, Makrigiannis A, Carlyle J Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model. J Immunol, 2015-02-13;194(6):2909-18. 2015-02-13 [PMID: 25681346] (Bioassay, Mouse)	Bioassay	Mouse
Oficjalska K, Raverdeau M, Aviello G, Wade S, Hickey A, Sheehan K, Corr S, Kay E, O'Neill L, Mills K, Creagh E Protective role for caspase-11 during acute experimental murine colitis. J Immunol, 2014-12-29;194(3):1252-60. 2014-12-29 [PMID: 25548224] (In Vivo, Mouse)	In Vivo	Mouse
Marcais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff Y, Gilson E, Vivier E, Walzer T The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat Immunol, 2014-06-29;15(8):749-57. 2014-06-29 [PMID: 24973821] (Bioassay, Mouse)	Bioassay	Mouse
Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi P, Jonjic S, Olive D, Dalod M, Vivier E, Nunes J Dok1 and Dok2 proteins regulate natural killer cell development and function. EMBO J, 2014-06-24;33(17):1928-40. 2014-06-24 [PMID: 24963146] (Bioassay, Mouse)	Bioassay	Mouse
He W, Yang C, Xia L, Zhao M, Ge R, Huang H, Ji Q, Yang P, Liu Z CD4(+) T cells from food allergy model are resistant to TCR-dependent apoptotic induction. Cytokine, 2014-04-16;68(1):32-9. 2014-04-16 [PMID: 24787054] (In Vivo, Mouse)	In Vivo	Mouse
Freeman B, Meyer C, Slifka M Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions. J Virol, 2014-04-16;88(13):7474-84. 2014-04-16 [PMID: 24741101] (Bioassay, Mouse)	Bioassay	Mouse
Chan , Christop, Martinet , Ludovic, Gilfillan , Susan, Souza-Fonseca-Guimaraes , Fernando, Chow , Melvyn T, Town , Liam, Ritchie , David S, Colonna , Marco, Andrews , Daniel M, Smyth , Mark J The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat Immunol, 2014-03-23;15(5):431-8. 2014-03-23 [PMID: 24658051] (Bioassay, Mouse)	Bioassay	Mouse
Duong S, Condotta S, Rai D, Martin M, Griffith T, Badovinac V Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. J Immunol, 2014-03-19;192(8):3618-25. 2014-03-19 [PMID: 24646738] (Bioassay, Mouse)	Bioassay	Mouse
Tyznik A, Verma S, Wang Q, Kronenberg M, Benedict C Distinct requirements for activation of NKT and NK cells during viral infection. J Immunol, 2014-03-14;192(8):3676-85. 2014-03-14 [PMID: 24634489] (Bioassay, Mouse)	Bioassay	Mouse
Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):34-43. 2013-10-24 [PMID: 24158516] (Bioassay, Mouse)	Bioassay	Mouse
Valcarcel M, Carrascal T, Crende O, Vidal-Vanaclocha F IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors. J Invest Dermatol, 2013-08-12;134(2):470-80. 2013-08-12 [PMID: 23938462] (Bioassay, Mouse)	Bioassay	Mouse
Wintges K, Beil F, Albers J, Jeschke A, Schweizer M, Claass B, Tiegs G, Amling M, Schinke T Impaired bone formation and increased osteoclastogenesis in mice lacking chemokine (C-C motif) ligand 5 (Ccl5). J Bone Miner Res, 2013-10-01;28(10):2070-80. 2013-10-01 [PMID: 23553711] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus. J. Virol., 2010-09-29;84(24):12703-12. 2010-09-29 [PMID: 20881038] (In Vivo, Mouse)	In Vivo	Mouse
Wiener Z, Pocza P, Racz M, Nagy G, Tolgyesi G, Molnar V, Jaeger J, Buzas E, Gorbe E, Papp Z, Rigo J, Falus A IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs. Int. Immunol., 2008-10-21;20(12):1565-73. 2008-10-21 [PMID: 18940934] (Bioassay, Mouse)	Bioassay	Mouse
Chandrasekar B, Patel DN, Mummidi S, Kim JW, Clark RA, Valente AJ Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J. Biol. Chem., 2007-12-17;283(7):4200-9. 2007-12-17 [PMID: 18086672] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY, Kimber I, Groves RW IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis. J. Leukoc. Biol., 2007-11-05;83(2):361-7. 2007-11-05 [PMID: 17984289] (In Vivo, Mouse)	In Vivo	Mouse
Hayashi N, Yoshimoto T, Izuhara K, Matsui K, Tanaka T, Nakanishi K T helper 1 cells stimulated with ovalbumin and IL-18 induce airway hyperresponsiveness and lung fibrosis by IFN-gamma and IL-13 production. Proc. Natl. Acad. Sci. U.S.A., 2007-08-31;104(37):14765-70. 2007-08-31 [PMID: 17766435] (In Vivo, Mouse)	In Vivo	Mouse
French AR, Sjolin H, Kim S, Koka R, Yang L, Young DA, Cerboni C, Tomasello E, Ma A, Vivier E, Karre K, Yokoyama WM DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections. J. Immunol., 2006-10-15;177(8):4981-90. 2006-10-15 [PMID: 17015680] (Bioassay, Mouse)	Bioassay	Mouse
Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C Control of Leishmania major in the absence of Tyk2 kinase. Eur. J. Immunol., 2004-02-01;34(2):519-29. 2004-02-01 [PMID: 14768057] (Bioassay, Mouse)	Bioassay	Mouse
Show All 35 Publications. Collapse Publications.

Array B002-5

• IL-18/IL-1F4 Antibodies
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• IL-18/IL-1F4 ELISA Kits
• IL-18/IL-1F4 Lysate
• IL-18/IL-1F4 Protein
• IL-18/IL-1F4 ELISAs
• IL-18/IL-1F4 Proteins and Enzymes