Recombinant Mouse Endoglycan/PODXL2 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Endoglycan, also called Podocalyxin-like 2 protein (PODXL2), is an extensively O-glycosylated type I transmembrane protein in the CD34 family of sialomucins (1, 2). Mature mouse Endoglycan consists of an extracellular domain (ECD) that contains an N-terminal acidic domain characterized by several polyglutamate tracts, a mucin domain, and a membrane-proximal globular domain. Within the ECD, mouse Endoglycan shares 96% and 75% amino acid identity with rat and human Endoglycan, respectively. Following the extracellular domain is a single transmembrane spanning helix and a charged cytoplasmic tail that contains a C-terminal PDZ‑domain binding motif (1, 3). The cytoplasmic domain of Endoglycan has been shown to bind to Na⁺/H⁺ exchanger regulatory factor-1 (NHERF-1), which acts as a scaffolding protein that links membrane proteins to the actin cytoskeleton (4). Endoglycan exists as a disulfide-linked homodimer that is expressed in vascular endothelium, smooth muscle, hematopoietic precursor populations and leukocyte subpopulations (1, 5). Endoglycan functions through its interactions with selectins and is involved in leukocyte-endothelial cell adhesion although, depending on cellular context and post-translational modifications, Endoglycan may also demonstrate anti-adhesive properties (2, 3, 5, 6).

Array 8365-EG

• Endoglycan/PODXL2 Antibodies
• Endoglycan/PODXL2 Lysate
• Endoglycan/PODXL2 Protein
• Endoglycan/PODXL2 Proteins and Enzymes