Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

4-1BB Ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that belongs to the TNF superfamily of molecules and plays an important role in immune response activation (1). The approximately 50 kDa mouse 4-1BB Ligand consists of an 82 aa cytoplasmic domain, a 21 aa transmembrane segment, and a 206 aa extracellular domain (ECD) (2). Within the ECD, mouse 4-1BB Ligand shares 36% and 86% aa sequence identity with human and rat 4-1BB Ligand, respectively. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes (3-9). A 26 kDa soluble form of 4-1BB Ligand can be released from the surface of activated cells and retains bioactivity (10). 4-1BB Ligand binds to 4-1BB/TNFRSF9/CD137 on activated CD4⁺ and CD8⁺ T cells, thymocytes, and NK cells as well as on monocytes, neutrophils, DC, and eosinophils. In response to 4-1BB Ligand binding, 4-1BB transduces a co-stimulatory signal that promotes the proliferation, activation, and survival of CD4⁺ and CD8⁺ T cells (4, 11, 12). T cell co-stimulation through CD28 is important for the initial T cell expansion, while 4-1BB acts later in the response (12, 13). 4-1BB Ligand function supports the survival and responsiveness of memory T cells during viral infection (13-15). Reverse signaling through
4-1BB Ligand on monocytes induces the production of inflammatory cytokines (5). On macrophages, 4-1BB Ligand associates in cis with TLR4 and enhances inflammatory cytokine production in response to TLR4 ligation (6). Its expression on early myeloid progenitor cells limits the development of dendritic cells, monocytes, and B cells (9).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: Bioassay, In Vivo.

Showing Publications 1 - 5 of 5.

Publications using 1246-4L/CF	Applications	Species
D Wan, S Ai, H Ouyang, L Cheng Activation of 4-1BB signaling in bone marrow stromal cells triggers bone loss via the p-38 MAPK-DKK1 axis in aged mice Experimental & Molecular Medicine, 2021-04-15;0(0):. 2021-04-15 [PMID: 33859350] (Bioassay, Mouse)	Bioassay	Mouse
Madireddi S, Eun S, Lee S, Nemcovicova I, Mehta A, Zajonc D, Nishi N, Niki T, Hirashima M, Croft M Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies. J Exp Med, 2014-06-23;211(7):1433-48. 2014-06-23 [PMID: 24958847] (Bioassay, Mouse)	Bioassay	Mouse
Mahmud , Shawn A, Manlove , Luke S, Schmitz , Heather, Xing , Yan, Wang , Yanyan, Owen , David L, Schenkel , Jason M, Boomer , Jonathan, Green , Jonathan, Yagita , Hideo, Chi , Hongbo, Hogquist , Kristin, Farrar , Michael Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol, 2014-03-16;15(5):473-81. 2014-03-16 [PMID: 24633226] (Bioassay, Mouse)	Bioassay	Mouse
Regulation of innate CD8+ T-cell activation mediated by cytokines. Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6. 2012-06-04 [PMID: 22665806] (Bioassay, Mouse)	Bioassay	Mouse
Kayamuro H, Yoshioka Y, Abe Y, Katayama K, Yoshida T, Yamashita K, Yoshikawa T, Hiroi T, Itoh N, Kawai Y, Mayumi T, Kamada H, Tsunoda S, Tsutsumi Y TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant. Biochem. Biophys. Res. Commun., 2009-05-04;384(3):296-300. 2009-05-04 [PMID: 19406102] (In Vivo, Mouse)	In Vivo	Mouse

Array 1246-4L/CF

• 4-1BB Ligand/TNFSF9 Antibodies
• 4-1BB Ligand/TNFSF9 Lysate
• 4-1BB Ligand/TNFSF9 Proteins
• 4-1BB Ligand/TNFSF9 Proteins and Enzymes