Recombinant Human VCAM-1/CD106 Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human VCAM-1 (CD106, INCAM-110) is a cell adhesion molecule and a member of the immunoglobulin superfamily. Alternatively spliced forms are known to occur, but the most common form is a type I transmembrane protein with a 674 amino acid extracellular segment that includes seven C2-type immunoglobulin domains. VCAM-1 is expressed by activated endothelial cells and certain other cell types including macrophages, dendritic cells, neurons, smooth muscle cells, fibroblasts, and oocytes. VCAM-1 binds to leukocyte integrins alpha 4 beta 1 (VLA-4) and alpha 4 beta 7. During the inflammatory adhesion mechanism, activated integrins halt rolling leukocytes and attach them firmly to the vascular endothelium. They do this by binding to their ligands, for example VCAM-1, on endothelium. The VCAM-1:VLA-4/ alpha 4 beta 7 interaction is also thought to be involved in the extravasation of white blood cells through the blood vessel wall to sites of inflammation. ELISA techniques have shown that detectable levels of soluble VCAM-1 are present in the biological fluids of apparently normal individuals. Furthermore, a number of studies have reported that levels of VCAM-1 may be elevated or lowered in subjects with a variety of pathological conditions.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: Adhesion Assay, Bioassay, Cell Culture.

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using 862-VC	Applications	Species
Ullo, MF;D'Amico, AE;Lavenus, SB;Logue, JS; The amoeboid migration of monocytes in confining channels requires the local remodeling of the cortical actin cytoskeleton by cofilin-1 Research square 2023-11-02 [PMID: 37961301] (Bioassay, Mouse)	Bioassay	Mouse
Ullo, MF;D'Amico, AE;Lavenus, SB;Logue, JS; The amoeboid migration of monocytes in confining channels requires the local remodeling of the cortical actin cytoskeleton by cofilin-1 bioRxiv : the preprint server for biology 2023-08-11 [PMID: 37609240] (Bioassay, Human)	Bioassay	Human
Wilkins, GC;Gilmour, J;Giannoudaki, E;Kirby, JA;Sheerin, NS;Ali, S; Dissecting the Therapeutic Mechanisms of Sphingosine-1-Phosphate Receptor Agonism during Ischaemia and Reperfusion International journal of molecular sciences 2023-07-07 [PMID: 37446370] (Bioassay, Human)	Bioassay	Human
Toffali, L;D'Ulivo, B;Giagulli, C;Montresor, A;Zenaro, E;Delledonne, M;Rossato, M;Iadarola, B;Sbarbati, A;Bernardi, P;Angelini, G;Rossi, B;Lopez, N;Linke, WA;Unger, A;Di Silvestre, D;Benazzi, L;De Palma, A;Motta, S;Constantin, G;Mauri, P;Laudanna, C; An isoform of the giant protein titin is a master regulator of human T lymphocyte trafficking Cell reports 2023-05-18 [PMID: 37204926] (Bioassay, Human)	Bioassay	Human
R Jing, I Scarfo, MA Najia, E Lummertz d, A Han, M Sanborn, T Bingham, C Kubaczka, DK Jha, M Falchetti, TM Schlaeger, TE North, MV Maus, GQ Daley EZH1 repression generates mature iPSC-derived CAR T�cells with enhanced antitumor activity Cell Stem Cell, 2022-08-04;29(8):1181-1196.e6. 2022-08-04 [PMID: 35931029] (Bioassay, Human)	Bioassay	Human
M Mastrogiov, P Vargas, T Rose, C Cuche, E Esposito, M Juzans, H Laude, A Schneider, M Bernard, S Goyard, C Renaudat, MN Ungeheuer, J Delon, A Alcover, V Di Bartolo The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration Science Advances, 2022-04-13;8(15):eabl5942. 2022-04-13 [PMID: 35417240] (Bioassay, Human)	Bioassay	Human
MC Schmid, SW Kang, H Chen, M Paradise, A Ghebremedh, MM Kaneda, SM Chin, A Do, DM Watterson, JA Varner PI3Kgamma stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation Nature Communications, 2022-04-01;13(1):1768. 2022-04-01 [PMID: 35365657] (Bioassay, Human)	Bioassay	Human
Z Lian, A Saeed, X Peng, XD Perrard, X Jia, A Hussain, CM Ballantyne, H Wu Monocyte phenotyping and management of lipoprotein X syndrome J Clin Lipidol, 2020-09-04;0(0):. 2020-09-04 [PMID: 33011137] (Bioassay, Human)	Bioassay	Human
A Natoni, ML Farrell, S Harris, C Falank, L Kirkham-Mc, MS Macauley, MR Reagan, M O' Dwyer Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model Haematologica, 2020-01-31;0(0):. 2020-01-31 [PMID: 31101754] (Bioassay, Human)	Bioassay	Human
D Karpova, MP Rettig, J Ritchey, D Cancilla, S Christ, L Gehrs, E Chendamara, MO Evbuomwan, M Holt, J Zhang, G Abou-Ezzi, H Celik, E Wiercinska, W Yang, F Gao, LG Eissenberg, RF Heier, SD Arnett, MJ Meyers, MJ Prinsen, DW Griggs, A Trumpp, PG Ruminski, DM Morrow, HB Bonig, DC Link, JF DiPersio Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells J. Clin. Invest., 2019-05-14;129(7):2745-2759. 2019-05-14 [PMID: 31085833] (Cell Culture, Human)	Cell Culture	Human
JM Laufer, R Lyck, DF Legler ZAP70 expression enhances chemokine-driven chronic lymphocytic leukemia cell migration and arrest by valency regulation of integrins FASEB J., 2018-03-28;0(0):fj201701452RR. 2018-03-28 [PMID: 29589978] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
G Petkau, Y Kawano, I Wolf, M Knoll, F Melchers MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice Eur. J. Immunol., 2018-03-15;0(0):. 2018-03-15 [PMID: 29505092] (Bioassay, Mouse)	Bioassay	Mouse
PJ Stewart-Hu, TP Szasz, ER Jaeger, MD Onken, JA Cooper, SC Morley Technical Advance: New in vitro method for assaying the migration of primary B cells using an endothelial monolayer as substrate J. Leukoc. Biol., 2017-06-21;0(0):. 2017-06-21 [PMID: 28637896] (Bioassay, Mouse)	Bioassay	Mouse
M Moslem, R Eggenschwi, C Wichmann, R Buhmann, T Cantz, R Henschler Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells Stem Cells Int, 2017-01-09;2017(0):7316354. 2017-01-09 [PMID: 28163724] (Bioassay, Human)	Bioassay	Human
Sophia Koutsogian Prolonged exposure to volatile anesthetic isoflurane worsens the outcome of polymicrobial abdominal sepsis Toxicol. Sci, 2017-04-01;0(0):. 2017-04-01 [PMID: 28003439] (Bioassay, Human)	Bioassay	Human
Peter Adriaensen Enhanced Biosensor Platforms for Detecting the Atherosclerotic Biomarker VCAM1 Based on Bioconjugation with Uniformly Oriented VCAM1-Targeting Nanobodies Biosensors (Basel), 2016-07-05;6(3):. 2016-07-05 [PMID: 27399790] (Bioassay, Human)	Bioassay	Human
María Luisa Lozano Novel mutations in RASGRP2 encoding for CalDAG-GEFI abrogate Rap1 activation causing platelet dysfunction Blood, 2016-05-27;0(0):. 2016-05-27 [PMID: 27235135] (Bioassay, Human)	Bioassay	Human
Mukovozov I, Huang Y, Zhang Q, Liu G, Siu A, Sokolskyy Y, Patel S, Hyduk S, Kutryk M, Cybulsky M, Robinson L The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells. J Immunol, 2015-08-21;195(7):3334-44. 2015-08-21 [PMID: 26297762] (Bioassay, Human)	Bioassay	Human
Chakraborty S, Hu S, Wu S, Karmenyan A, Chiou A The interaction affinity between vascular cell adhesion molecule-1 (VCAM-1) and very late antigen-4 (VLA-4) analyzed by quantitative FRET. PLoS ONE, 2015-03-20;10(3):e0121399. 2015-03-20 [PMID: 25793408] (Bioassay, Human)	Bioassay	Human
Mahadev V, Starr R, Wright S, Martinez C, Jensen M, Barish M, Forman S, Brown C Cytokine induction of VCAM-1 but not IL13Ralpha2 on glioma cells: a tale of two antibodies. PLoS ONE, 2014-05-02;9(5):e95123. 2014-05-02 [PMID: 24787244] (Bioassay, Human)	Bioassay	Human
Chaar V, Laurance S, Lapoumeroulie C, Cochet S, De Grandis M, Colin Y, Elion J, Le Van Kim C, El Nemer W Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation. J Biol Chem, 2014-03-10;289(16):11512-21. 2014-03-10 [PMID: 24616094] (Bioassay, Human)	Bioassay	Human
Huang J, Filipe A, Rahuel C, Bonnin P, Mesnard L, Guerin C, Wang Y, Le Van Kim C, Colin Y, Tharaux P Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice. Kidney Int, 2014-01-15;85(5):1123-36. 2014-01-15 [PMID: 24429403] (Adhesion Assay, Human)	Adhesion Assay	Human
Lee J, Sohn J, Ryu S, Hong C, Moon K, Park J A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling. J Cell Mol Med, 2013-07-16;17(10):1271-81. 2013-07-16 [PMID: 23855490] (Bioassay, Mouse)	Bioassay	Mouse
Chiang Y, Ho K, Sun C, Chiu J, Lee F, Liao F, Yang-Yen H, Yen J CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration. PLoS ONE, 2013-04-19;8(4):e61761. 2013-04-19 [PMID: 23620790] (Bioassay, Human)	Bioassay	Human
Woolf E, Grigorova I, Sagiv A, Grabovsky V, Feigelson SW, Shulman Z, Hartmann T, Sixt M, Cyster JG, Alon R Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat. Immunol., 2007-08-26;8(10):1076-85. 2007-08-26 [PMID: 17721537] (Bioassay, Human)	Bioassay	Human
Show All 25 Publications. Collapse Publications.

Array 862-VC

• VCAM-1/CD106 Antibodies
• VCAM-1/CD106 Antibody Pair
• VCAM-1/CD106 ELISA Kits
• VCAM-1/CD106 Lysate
• VCAM-1/CD106 Proteins
• VCAM-1/CD106 ELISAs
• VCAM-1/CD106 Proteins and Enzymes