Recombinant Human Sonic Hedgehog/Shh (C24II) N-Terminus

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Sonic Hedgehog (Shh) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation as well as T cell determination. In adult tissue Shh is associated with cancer development and tissue remodeling following injury (1-3). Human Shh encodes a 462 amino acid (aa) precursor protein that is autocatalytically processed to yield a non-glycosylated 19 kDa N-terminal fragment (Shh-N) and a glycosylated 25 kDa C-terminal protein (Shh-C) (4). Shh-C, which is responsible for the intramolecular processing of Shh, is rapidly degraded following Shh proteolysis (5). Shh-N is highly conserved, sharing >98% aa identity between mouse, human, rat, canine, porcine, and chicken Shh-N. Shh-N can be palmitoylated at its
N-terminal cysteine and modified by cholesterol addition at its C-terminus (6). These modifications contribute to the membrane tethering of Shh as well as its assembly into various sized multimers (6-9). Lipid modification and multimerization greatly increase Shh-N receptor binding affinity and signaling potency (5, 6, 8, 9). Monomeric and multimeric Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17 (10-12). Modifications also extend the effective range of Shh functionality and are required for the development of protein gradients important in tissue morphogenesis (9, 13). Canonical signaling of Shh is mediated by a multicomponent receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO) (14). The binding of Shh to PTCH releases the basal repression of SMO by PTCH. Shh activity can also be regulated through interactions with heparin, glypicans, and membrane-associated Hip (hedgehog interacting protein) (13, 15, 16).

We have publications tested in 6 confirmed species: Human, Mouse, Rat, Bovine, Porcine, Xenopus.

We have publications tested in 4 applications: Bioassay, Cell Culture, In Vivo, Pull-Down Assay.

Showing Publications 1 - 10 of 61. Show All 61 Publications. Collapse Publications.

Publications using 1845-SH	Applications	Species
Papandreou, A;Singh, N;Gianfrancesco, L;Budinger, D;Barwick, K;Agrotis, A;Luft, C;Shao, Y;Lenaerts, AS;Gregory, A;Jeong, SY;Hogarth, P;Hayflick, S;Barral, S;Kriston-Vizi, J;Gissen, P;Kurian, MA;Ketteler, R; Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency bioRxiv : the preprint server for biology 2023-09-13 [PMID: 37745522] (Bioassay, Human)	Bioassay	Human
Daggubati, V;Vykunta, A;Choudhury, A;Qadeer, Z;Mirchia, K;Saulnier, O;Zakimi, N;Hines, K;Paul, M;Wang, L;Jura, N;Xu, L;Reiter, J;Taylor, M;Weiss, W;Raleigh, D; Hedgehog target genes regulate lipid metabolism to drive basal cell carcinoma and medulloblastoma Research square 2023-08-03 [PMID: 37577529] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Ito, R;Kimura, A;Hirose, Y;Hatano, Y;Mima, A;Mae, SI;Keidai, Y;Nakamura, T;Fujikura, J;Nishi, Y;Ohta, A;Toyoda, T;Inagaki, N;Osafune, K; Elucidation of HHEX in pancreatic endoderm differentiation using a human iPSC differentiation model Scientific reports 2023-05-29 [PMID: 37248264] (Bioassay, Human)	Bioassay	Human
Ö Karabiyik, GD Nozhatzade, A Tuncer, G Torun Köse, E Hacihasano, F Sahin, E Aysan Production of parathyroid-like cells from thyroid stem cells in co-culture environment Medicine, 2022-12-02;101(48):e32009. 2022-12-02 [PMID: 36482540] (Bioassay, Human)	Bioassay	Human
X Li, PJ Gordon, JA Gaynes, AW Fuller, R Ringuette, CP Santiago, V Wallace, S Blackshaw, P Li, EM Levine Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis Elife, 2022-12-02;11(0):. 2022-12-02 [PMID: 36459481] (Cell Culture, Mouse)	Cell Culture	Mouse
DS Lee, YJ Song, HR Gug, JH Lee, HS Bae, JC Park Nuclear Factor I-C Regulates Stemness Genes and Proliferation of Stem Cells in Various Mineralized Tissue through Epithelial-Mesenchymal Interactions in Dental Epithelial Stem Cells Stem Cells International, 2022-09-27;2022(0):1092184. 2022-09-27 [PMID: 36213683] (Cell Culture, Mouse)	Cell Culture	Mouse
JS Fleck, SMJ Jansen, D Wollny, F Zenk, M Seimiya, A Jain, R Okamoto, M Santel, Z He, JG Camp, B Treutlein Inferring and perturbing cell fate regulomes in human brain organoids Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198796] (Bioassay, Human)	Bioassay	Human
MA Hossain, M Hasegawa-O, Y Manome, M Igarashi, C Wu, K Suzuki, J Igarashi, T Iwamoto, HJ Okano, Y Eto Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells Oncogene, 2022-02-21;31(0):100852. 2022-02-21 [PMID: 35782608] (Bioassay, Human)	Bioassay	Human
JSY Tan, B Lee, J Lim, DR Ma, JX Goh, SY Goh, MY Gulam, SM Koh, WW Lee, L Feng, Q Wang, Y Chao, O Rötzschke, EK Tan Parkinson's Disease-Specific Autoantibodies against the Neuroprotective Co-Chaperone STIP1 Cells, 2022-05-16;11(10):. 2022-05-16 [PMID: 35626686] (Bioassay, Human)	Bioassay	Human
M Lo, A Sharir, MD Paul, H Torosyan, C Agnew, A Li, C Neben, P Marangoni, L Xu, DR Raleigh, N Jura, OD Klein CNPY4 inhibits the Hedgehog pathway by modulating membrane sterol lipids Nature Communications, 2022-05-03;13(1):2407. 2022-05-03 [PMID: 35504891] (Bioassay, Mouse)	Bioassay	Mouse
A Moore, K Chinnaiya, DW Kim, S Brown, I Stewart, S Robins, GKC Dowsett, C Muir, M Travaglio, JE Lewis, F Ebling, S Blackshaw, A Furley, M Placzek Loss of Function of the Neural Cell Adhesion Molecule NrCAM Regulates Differentiation, Proliferation and Neurogenesis in Early Postnatal Hypothalamic Tanycytes Frontiers in Neuroscience, 2022-04-07;16(0):832961. 2022-04-07 [PMID: 35464310] (Bioassay, Human)	Bioassay	Human
L Torz, K Niss, S Lundh, JC Rekling, CD Quintana, SED Frazier, AJ Mercer, A Cornea, CV Bertelsen, MK Gerstenber, AMK Hansen, M Guldbrandt, J Lykkesfeld, LM John, JC Villaescus, N Petersen NPFF Decreases Activity of Human Arcuate NPY Neurons: A Study in Embryonic-Stem-Cell-Derived Model International Journal of Molecular Sciences, 2022-03-17;23(6):. 2022-03-17 [PMID: 35328681] (Cell Culture, Human)	Cell Culture	Human
MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)	Bioassay	Human
K Kerekes, M Trexler, L Bányai, L Patthy Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog Cells, 2021-12-10;10(12):. 2021-12-10 [PMID: 34944004] (Pull-Down Assay, Human)	Pull-Down Assay	Human
AM Earley, LF Burbulla, D Krainc, R Awatramani Identification of ASCL1 as a determinant for human iPSC-derived dopaminergic neurons Scientific Reports, 2021-11-15;11(1):22257. 2021-11-15 [PMID: 34782629] (Bioassay, Human)	Bioassay	Human
A Azatyan, S Zhang, A Darabi, P Siesjö, T Wang, PG Zaphiropou Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors Cancers, 2021-10-13;13(20):. 2021-10-13 [PMID: 34680287] (Cell Culture, Human)	Cell Culture	Human
K Nakai, T Shiga, R Yasuhara, AK Sarkar, Y Abe, S Nakamura, Y Hoashi, K Kotani, S Tatsumoto, H Ishikawa, Y Go, T Inoue, K Mishima, W Akamatsu, K Baba In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells Scientific Reports, 2021-07-29;11(1):15437. 2021-07-29 [PMID: 34326453] (Bioassay, Human)	Bioassay	Human
JS Fleck, F Sanchís-Ca, Z He, M Santel, MJ Boyle, JG Camp, B Treutlein Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases Cell Stem Cell, 2021-03-11;0(0):. 2021-03-11 [PMID: 33711282] (Bioassay, Human)	Bioassay	Human
L Cui, J Zheng, Q Zhao, JR Chen, H Liu, G Peng, Y Wu, C Chen, Q He, H Shi, S Yin, RA Friedman, Y Chen, MX Guan Mutations of MAP1B encoding a microtubule-associated phosphoprotein cause sensorineural hearing loss JCI Insight, 2020-12-03;5(23):. 2020-12-03 [PMID: 33268592] (Bioassay, Human)	Bioassay	Human
JL Goggi, L Qiu, MC Liao, S Khanapur, L Jiang, R Boominatha, SV Hartimath, P Cheng, FF Yong, V Soh, X Deng, YM Lin, A Haslop, PW Tan, X Zeng, JWL Lee, Z Zhang, P Sadasivam, EK Tan, SK Luthra, WD Shingleton, SKW Oh, L Zeng, EG Robins Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease Stem Cell Res Ther, 2020-08-08;11(1):347. 2020-08-08 [PMID: 32771055] (Bioassay, Human)	Bioassay	Human
CR Cochrane, V Vaghjiani, A Szczepny, WSN Jayasekara, A Gonzalez-R, K Kikuchi, GW McCaughan, A Burgess, DJ Gough, DN Watkins, JE Cain Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling J. Clin. Invest., 2020-08-03;0(0):. 2020-08-03 [PMID: 32568216] (Bioassay, Mouse)	Bioassay	Mouse
C Yang, L Yong, C Liang, Y Li, Y Ma, F Wei, L Jiang, H Zhou, G He, X Pan, B Hai, J Wu, Y Xu, Z Liu, X Liu Genetic landscape and ligand-dependent activation of sonic hedgehog-Gli1 signaling in chordomas: a novel therapeutic target Oncogene, 2020-05-14;0(0):. 2020-05-14 [PMID: 32404987] (Cell Culture, Human)	Cell Culture	Human
B Ghaleh, J Thireau, O Cazorla, R Soleti, V Scheuerman, A Bizé, L Sambin, F Roubille, R Andriantsi, MC Martinez, A Lacampagne Cardioprotective effect of sonic hedgehog ligand in pig models of ischemia reperfusion Theranostics, 2020-03-04;10(9):4006-4016. 2020-03-04 [PMID: 32226535] (In Vivo, Porcine)	In Vivo	Porcine
CT Hong, KY Chen, W Wang, JY Chiu, D Wu, TY Chao, CJ Hu, KD Chau, OA Bamodu Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of &alpha-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling Cells, 2020-03-17;9(3):. 2020-03-17 [PMID: 32192190] (Cell Culture, Human)	Cell Culture	Human
SL Boddy, R Romero-Gue, AR Ji, C Unger, L Corns, W Marcotti, MN Rivolta Generation of Otic Lineages from Integration-Free Human-Induced Pluripotent Stem Cells Reprogrammed by mRNAs Stem Cells Int, 2020-03-01;2020(0):3692937. 2020-03-01 [PMID: 32190057] (Bioassay, Human)	Bioassay	Human
WW Feng, O Wilkins, S Bang, M Ung, J Li, J An, C Del Genio, K Canfield, J DiRenzo, W Wells, A Gaur, RB Robey, JY Guo, RL Powles, C Sotiriou, L Pusztai, M Febbraio, C Cheng, WB Kinlaw, M Kurokawa CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies Cell Rep, 2019-12-10;29(11):3405-3420.e5. 2019-12-10 [PMID: 31825825] (Bioassay, Mouse)	Bioassay	Mouse
J Ferent, S Constable, ED Gigante, PT Yam, LE Mariani, E Legué, KF Liem, T Caspary, F Charron The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance Cell Rep, 2019-12-10;29(11):3356-3366.e3. 2019-12-10 [PMID: 31825820] (Bioassay, Mouse)	Bioassay	Mouse
CL White, WSN Jayasekara, D Picard, J Chen, DN Watkins, JE Cain, M Remke, DJ Gough A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma Cancers (Basel), 2019-11-01;11(11):. 2019-11-01 [PMID: 31683879] (Cell Culture, Mouse)	Cell Culture	Mouse
JP Zanin, JL Verpeut, Y Li, MW Shiflett, SS Wang, V Santhakuma, WJ Friedman The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors J. Neurosci., 2019-10-03;0(0):. 2019-10-03 [PMID: 31582529] (Bioassay, Rat)	Bioassay	Rat
S Park, JY Kim, S Myung, N Jung, Y Choi, SC Jung Differentiation of Motor Neuron-Like Cells from Tonsil-Derived Mesenchymal Stem Cells and Their Possible Application to Neuromuscular Junction Formation Int J Mol Sci, 2019-06-01;20(11):. 2019-06-01 [PMID: 31159418] (Bioassay, Human)	Bioassay	Human
L Ma, Y Wang, Y Hui, Y Du, Z Chen, H Feng, S Zhang, N Li, J Song, Y Fang, X Xu, L Shi, B Zhang, J Cheng, S Zhou, L Liu, X Zhang WNT/NOTCH Pathway Is Essential for the Maintenance and Expansion of Human MGE Progenitors Stem Cell Reports, 2019-05-02;0(0):. 2019-05-02 [PMID: 31056478] (Bioassay, Human)	Bioassay	Human
SK Riaz, Y Ke, F Wang, MA Kayani, MFA Malik Influence of SHH/GLI1 axis on EMT mediated migration and invasion of breast cancer cells Sci Rep, 2019-04-29;9(1):6620. 2019-04-29 [PMID: 31036836] (Bioassay, Human)	Bioassay	Human
M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients Front Cell Neurosci, 2019-02-22;13(0):58. 2019-02-22 [PMID: 30853899] (Bioassay, Human)	Bioassay	Human
J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects Cell Rep, 2019-02-26;26(9):2494-2508.e7. 2019-02-26 [PMID: 30811996] (Bioassay, Human)	Bioassay	Human
C Lang, KR Campbell, BJ Ryan, P Carling, M Attar, J Vowles, OV Perestenko, R Bowden, F Baig, M Kasten, MT Hu, SA Cowley, C Webber, R Wade-Marti Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes Cell Stem Cell, 2018-11-29;0(0):. 2018-11-29 [PMID: 30503143]
KKB Tan, WWM Lim, C Chai, M Kukumberg, KL Lim, ELK Goh, EKF Yim Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Sci Rep, 2018-06-22;8(1):9567. 2018-06-22 [PMID: 29934644] (Bioassay, Human)	Bioassay	Human
C Xu, C Zou, M Hussain, W Shi, Y Shao, Z Jiang, X Wu, M Lu, J Wu, Q Xie, Y Ke, F Long, L Tang, X Wu High expression of Sonic hedgehog in allergic airway epithelia contributes to goblet cell metaplasia Mucosal Immunol, 2018-06-04;0(0):. 2018-06-04 [PMID: 29867080] (Bioassay, Human)	Bioassay	Human
X Hu, JW Lee, X Zheng, J Zhang, X Lin, Y Song, B Wang, X Hu, HH Chang, Y Chen, CP Lin, Y Zhang Efficient induction of functional ameloblasts from human keratinocyte stem cells Stem Cell Res Ther, 2018-05-02;9(1):126. 2018-05-02 [PMID: 29720250] (Bioassay, Human)	Bioassay	Human
JY Kim, JS Lee, HS Hwang, DR Lee, CY Park, SJ Jung, YR You, DS Kim, DW Kim Wnt signal activation induces midbrain specification through direct binding of the beta-catenin/TCF4 complex to the EN1 promoter in human pluripotent stem cells Exp. Mol. Med., 2018-04-13;50(4):24. 2018-04-13 [PMID: 29650976] (Bioassay, Human)	Bioassay	Human
C Chen, MB Breslin, MS Lan Sonic hedgehog signaling pathway promotes INSM1 transcription factor in neuroendocrine lung cancer Cell. Signal., 2018-03-01;46(0):83-91. 2018-03-01 [PMID: 29501727] (Bioassay, Human)	Bioassay	Human
X Ye, W Hong, B Hao, G Peng, L Huang, Z Zhao, Y Zhou, M Zheng, C Li, C Liang, E Yi, J Pu, B Li, P Ran PM2.5 promotes human bronchial smooth muscle cell migration via the sonic hedgehog signaling pathway Respir. Res., 2018-03-02;19(1):37. 2018-03-02 [PMID: 29499705] (Bioassay, Human)	Bioassay	Human
G Shall, M Menosky, S Decker, P Nethala, R Welchko, X Leveque, M Lu, M Sandstrom, U Hochgeschw, J Rossignol, G Dunbar Effects of Passage Number and Differentiation Protocol on the Generation of Dopaminergic Neurons from Rat Bone Marrow-Derived Mesenchymal Stem Cells Int J Mol Sci, 2018-03-02;19(3):. 2018-03-02 [PMID: 29498713] (Bioassay, Rat)	Bioassay	Rat
DM Fink, MR Sun, GW Heyne, JL Everson, HM Chung, S Park, MD Sheets, RJ Lipinski Coordinated d-cyclin/Foxd1 activation drives mitogenic activity of Sonic Hedgehog signaling pathway Cell. Signal., 2017-12-26;0(0):. 2017-12-26 [PMID: 29284139] (Bioassay, Mouse)	Bioassay	Mouse
SY Xie, G Li, C Han, YY Yu, N Li RKIP reduction enhances radioresistance by activating the Shh signaling pathway in non-small-cell lung cancer Onco Targets Ther, 2017-11-23;10(0):5605-5619. 2017-11-23 [PMID: 29200875] (Bioassay, Human)	Bioassay	Human
S Kasiri, C Shao, B Chen, AN Wilson, P Yenerall, BC Timmons, L Girard, H Tian, C Behrens, II Wistuba, AF Gazdar, J Kim GLI1 blockade potentiates the antitumor activity of PI3K antagonists in lung squamous cell carcinoma Cancer Res., 2017-06-26;0(0):. 2017-06-26 [PMID: 28652248] (Bioassay, Human)	Bioassay	Human
DJM Bergen, NL Stevenson, REH Skinner, DJ Stephens, CL Hammond The Golgi matrix protein giantin is required for normal cilia function in zebrafish Biol Open, 2017-08-15;0(0):. 2017-08-15 [PMID: 28546340] (Bioassay, Human)	Bioassay	Human
L J Spicer G protein-coupled receptor 34 in ovarian granulosa cells of cattle: changes during follicular development and potential functional implications Domest. Anim. Endocrinol, 2016-12-11;59(0):90-99. 2016-12-11 [PMID: 28040605] (Bioassay, Bovine)	Bioassay	Bovine
Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis Sci Rep, 2016-11-21;6(0):37445. 2016-11-21 [PMID: 27869174] (Bioassay, Human)	Bioassay	Human
Hai Zhang Anti-proliferation of breast cancer cells with itraconazole: Hedgehog pathway inhibition induces apoptosis and autophagic cell death Cancer Lett., 2016-10-31;0(0):. 2016-10-31 [PMID: 27810405] (Bioassay, Human)	Bioassay	Human
Matevossian A, Resh M Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer, 2015-04-01;14(0):72. 2015-04-01 [PMID: 25889650] (Bioassay, Human)	Bioassay	Human
Belgacem Y, Borodinsky L Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. Proc Natl Acad Sci U S A, 2015-03-17;112(13):4140-5. 2015-03-17 [PMID: 25829542] (Bioassay, Xenopus)	Bioassay	Xenopus
Tang C, Pan Y, Luo H, Xiong W, Zhu H, Ruan H, Wang J, Zou C, Tang L, Iguchi T, Long F, Wu X Hedgehog signaling stimulates the conversion of cholesterol to steroids. Cell Signal, 2015-01-10;27(3):487-97. 2015-01-10 [PMID: 25582983] (Bioassay, Human)	Bioassay	Human
Hartfield , Elizabet, Yamasaki-Mann , Michiko, Ribeiro Fernandes , Hugo J, Vowles , Jane, James , William, Cowley , Sally A, Wade-Martins , Richard Physiological characterisation of human iPS-derived dopaminergic neurons. PLoS ONE, 2014-02-21;9(2):e87388. 2014-02-21 [PMID: 24586273] (Bioassay, Human)	Bioassay	Human
Williams E, Zhong X, Mohamed A, Li R, Liu Y, Dong Q, Ananiev G, Mok J, Lin B, Lu J, Chiao C, Cherney R, Li H, Zhang S, Chang Q Mutant astrocytes differentiated from Rett syndrome patients-specific iPSCs have adverse effects on wild-type neurons. Hum Mol Genet, 2014-01-12;23(11):2968-80. 2014-01-12 [PMID: 24419315] (Bioassay, Human)	Bioassay	Human
Saito A, Kanemoto S, Zhang Y, Asada R, Hino K, Imaizumi K Chondrocyte proliferation regulated by secreted luminal domain of ER stress transducer BBF2H7/CREB3L2. Mol Cell, 2013-12-12;53(1):127-39. 2013-12-12 [PMID: 24332809] (Bioassay, Human)	Bioassay	Human
Chen , Dongfeng, Persson , Annette, Sun , Yingyu, Salford , Leif G, Nord , David Gi, Englund , Elisabet, Jiang , Tao, Fan , Xiaolong Better prognosis of patients with glioma expressing FGF2-dependent PDGFRA irrespective of morphological diagnosis. PLoS ONE, 2013-04-22;8(4):e61556. 2013-04-22 [PMID: 23630597] (Bioassay, Human)	Bioassay	Human
Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol, 2013-04-21;31(5):440-7. 2013-04-21 [PMID: 23604284] (Bioassay, Human)	Bioassay	Human
Cai J, Schleidt S, Pelta-Heller J, Hutchings D, Cannarsa G, Iacovitti L BMP and TGF-beta pathway mediators are critical upstream regulators of Wnt signaling during midbrain dopamine differentiation in human pluripotent stem cells. Dev Biol, 2013-01-23;376(1):62-73. 2013-01-23 [PMID: 23352789] (Bioassay, Human)	Bioassay	Human
Strand MF, Wilson SR, Dembinski JL, Holsworth DD, Khvat A, Okun I, Petersen D, Krauss S A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model. PLoS ONE, 2011-06-15;6(6):e19904. 2011-06-15 [PMID: 21698280] (Bioassay, Mouse)	Bioassay	Mouse
Fabre PJ, Shimogori T, Charron F Segregation of ipsilateral retinal ganglion cell axons at the optic chiasm requires the Shh receptor Boc. J. Neurosci., 2010-01-06;30(0):266. 2010-01-06 [PMID: 20053908] (Bioassay, Mouse)	Bioassay	Mouse
Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery. J. Cell Biol., 2008-03-10;180(5):897-904. 2008-03-10 [PMID: 18332216] (Bioassay, Human)	Bioassay	Human
Show All 61 Publications. Collapse Publications.

Array 1845-SH

• Sonic Hedgehog/Shh Antibodies
• Sonic Hedgehog/Shh ELISA Kits
• Sonic Hedgehog/Shh Lysate
• Sonic Hedgehog/Shh Proteins
• Sonic Hedgehog/Shh Proteins and Enzymes
• Sonic Hedgehog/Shh ELISAs