Recombinant Human Semaphorin 6A Fc Chimera Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Semaphorin 6A (Sema6A) is an approximately 120 kDa member of the class 6 subfamily of semaphorins, a large, highly conserved family of signaling molecules that affect multiple processes including axon guidance, cell migration, synaptogenesis, dendritic spine formation, and angiogenesis (1). The class 6 semaphorins are type I transmembrane glycoproteins that contain a characteristic extracellular beta  propeller N-terminal semaphorin (sema) domain and also an extracellular
plexin-semaphorin-integrin (PSI) domain (1, 2). Within the ECD, human Sema6A shares 94% and 93% aa sequence identity with mouse and rat Sema6A, respectively. Alternative splicing generates an additional isoform with a 17 aa insertion between the sema domain and transmembrane segment. Sema6A interacts with Plexin A4
(3-7) to induce growth cone collapse and regulate the axon pathfinding of sympathetic neurons (3, 7, 8), cerebellar cortex granule cells (9), hippocampus CA3 region mossy fibers (6), corticospinal tract axons (5, 10), and retinal neurons (4). Plexin A2 can compete with Plexin A4 for Sema6A binding and thereby limit axon repulsion (6). In addition, Sema6A and Plexin A4 are co-expressed on dorsal root ganglion sensory neurons and associate in cis; this prevents in trans interactions and subsequent axon repulsion (7). Sema6A is additionally expressed on vascular endothelial cells where it regulates VEGF R2 responsiveness during angiogenesis (11). In contrast, exogenous Sema6A can inhibit the survival of the HUVEC cell line in a Plexin A4 independent manner (11, 12). Sema6A is also expressed on myelinating oligodendrocytes, Langerhans cells, and some dendritic cells (13, 14).

We have publications tested in 2 confirmed species: Human, Zebrafish.

We have publications tested in 2 applications: Bioassay, Reference Standard.

Showing Publications 1 - 7 of 7.

Publications using 1146-S6	Applications	Species
Farah, EN;Hu, RK;Kern, C;Zhang, Q;Lu, TY;Ma, Q;Tran, S;Zhang, B;Carlin, D;Monell, A;Blair, AP;Wang, Z;Eschbach, J;Li, B;Destici, E;Ren, B;Evans, SM;Chen, S;Zhu, Q;Chi, NC; Spatially organized cellular communities form the developing human heart Nature 2024-03-13 [PMID: 38480880] (Bioassay, Human)	Bioassay	Human
S Tian, X Xiong, J Zeng, S Wang, BJ Tremblay, P Chen, B Chen, M Liu, P Chen, K Sheng, D Zeve, W Qi, DT Breault, C Rodríguez, R Gerhard, R Jin, AC Doxey, M Dong Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants Nature Communications, 2022-11-09;13(1):6786. 2022-11-09 [PMID: 36351897] (Reference Standard, Human)	Reference Standard	Human
X Tian, H Yan, J Li, S Wu, J Wang, L Fan Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif GTPase Activation Downstream of MAPKs and PI3K Signaling Int J Mol Sci, 2017-01-13;18(1):. 2017-01-13 [PMID: 28098758] (Bioassay, Human)	Bioassay	Human
Ebert A, Childs S, Hehr C, Cechmanek P, McFarlane S Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development, 2014-06-01;141(12):2473-82. 2014-06-01 [PMID: 24917502] (Bioassay, Zebrafish)	Bioassay	Zebrafish
Segarra , Marta, Ohnuki , Hidetaka, Maric , Dragan, Salvucci , Ombretta, Hou , Xu, Kumar , Anil, Li , Xuri, Tosato , Giovanna Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood, 2012-09-24;120(19):4104-15. 2012-09-24 [PMID: 23007403] (Bioassay, Human)	Bioassay	Human
Tran-Van H, Avota E, Bortlein C, Mueller N, Schneider-Schaulies S Measles virus modulates dendritic cell/T-cell communication at the level of plexinA1/neuropilin-1 recruitment and activity. Eur. J. Immunol., 2011-01-01;41(1):151-63. 2011-01-01 [PMID: 21182086] (Bioassay, Human)	Bioassay	Human
Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chedotal A Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells. Nat. Neurosci., 2008-03-09;11(4):440-9. 2008-03-09 [PMID: 18327254] (Bioassay, Human)	Bioassay	Human

Array 1146-S6

• Semaphorin 6A Antibodies
• Semaphorin 6A Lysate
• Semaphorin 6A Protein
• Semaphorin 6A Proteins and Enzymes