Home » IL-17RA/IL-17R » IL-17RA/IL-17R Proteins » Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF
Novus Biologicals products are now on bio-techne.com

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

 (4 Publications)
 See All Related
Submit a Review

Images

 
There are currently no images for IL-17RA/IL-17R (177-IR).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

Order Details

Novus Biologicals is part of Bio-Techne

Shop this product on bio-techne.com

Novus Biologicals, part of Bio-Techne, offers 100% Guarantee

Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its ability to inhibit IL-17-induced IL-6 secretion by NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 0.03‑0.1 µg/mL in the presence of 10 ng/mL recombinant human IL‑17.
Source
Mouse myeloma cell line, NS0-derived human IL-17 RA/IL-17 R protein
Human IL-17 RA/IL-17 R
(Leu33-Trp 320)
Accession # Q96F46		 IEGRMD Human IgG1
(Pro100-Lys330)
N-terminus C-terminus
Accession #
N-terminal Sequence
Leu33
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
IL17RA
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
60 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
100 kDa, reducing conditions
Publications
Read Publications using
177-IR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF

  • CD217 antigen
  • CD217
  • Cdw217
  • CDw217interleukin 17 receptor
  • hIL-17R
  • IL-17 R
  • IL-17 RA
  • IL-17 receptor A
  • IL17RA
  • IL-17RA
  • IL-17RAMGC10262
  • IL17Rinterleukin-17 receptor A
  • interleukin 17 receptor A

Background

Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22. Human IL‑17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy‑proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL‑17 R is 69% identical to the mouse IL‑17 R. The signaling events of IL‑17 includes activation of NF‑ kappa B and JNK, and require TNF receptor‑associated factors 6 (TRAF6) in the signaling pathway.

  1. Yao, Z. et al. (1997) Cytokine 9:794.
  2. Schwander, R. et al. (2000) J. Exp. Med. 191:1233.

Customers Who Viewed This Item Also Viewed...

IL-17/IL-17A
[Biotin]
DY421
N/A IL-17/IL-17A [Biotin]
(189 Publications)
Species: Mu
Applications: ELISA
IL-17F [Biotin]
DY1335B
N/A IL-17F [Biotin]
N/A IL-17F [Biotin]
(13 Publications)
Species: Hu
Applications: ELISA
IL-6 [HRP]
M6000B
N/A IL-6 [HRP]
N/A IL-6 [HRP]
N/A IL-6 [HRP]
(643 Publications)
Species: Mu
Applications: ELISA
TNF-alpha
[Unconjugated]
210-TA
SDS-PAGE TNF-alpha [Unconjugated]
Bioactivity TNF-alpha [Unconjugated]
SEC-MALS TNF-alpha [Unconjugated]
(3 Reviews)
(809 Publications)
Species: Hu
Applications: BA
IL-17RC Antibody
AF2270
Neutralization IL-17RC Antibody
Flow Cytometry IL-17RC Antibody
(6 Publications)
Species: Mu
Applications: CyTOF-ready, Flow, Neut, WB
CXCL8/IL-8
Antibody (6217) [Unco ...
MAB208
Neutralization CXCL8/IL-8 Antibody (6217) [Unconjugated]
Immunocytochemistry CXCL8/IL-8 Antibody (6217) [Unconjugated]
Western Blot CXCL8/IL-8 Antibody (6217) [Unconjugated]
(1 Review)
(182 Publications)
Species: Hu
Applications: CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), ICC, ICFlow, Neut, Simple Western, WB
IL-23A/IL-23 P19
[Unconjugated]
1290-IL
IL-23A/IL-23 P19 [Unconjugated]
(114 Publications)
Species: Hu
Applications: BA
IL-22
[Unconjugated]
782-IL/CF
SDS-PAGE IL-22 [Unconjugated]
Bioactivity IL-22 [Unconjugated]
(65 Publications)
Species: Hu
Applications: BA
CD4 Antibody - BSA
Free
NBP1-19371
Immunohistochemistry-Frozen CD4 Antibody - BSA Free
Immunohistochemistry-Paraffin CD4 Antibody - BSA Free
Flow Cytometry CD4 Antibody - BSA Free
(9 Reviews)
(50 Publications)
Species: Ca, Hu, Mu, Po, Rb, Rt
Applications: Dual ISH-IHC, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, Simple Western, WB
IL-17RB Antibody
(170220)
MAB1207
Flow Cytometry IL-17RB Antibody (170220)
(7 Publications)
Species: Hu
Applications: CyTOF-ready, Flow, WB
IL-17RC Antibody
AF2270
Neutralization IL-17RC Antibody
Flow Cytometry IL-17RC Antibody
(6 Publications)
Species: Mu
Applications: CyTOF-ready, Flow, Neut, WB
TRAF3IP2 Antibody
NB100-56740
Simple Western TRAF3IP2 Antibody
Western Blot TRAF3IP2 Antibody
Western Blot TRAF3IP2 Antibody
(13 Publications)
Species: Hu, Mu
Applications: IHC, IHC-P, IP, Simple Western, WB
IL-17D Antibody
(246018) [Unconjugate
MAB15041
Immunohistochemistry IL-17D Antibody (246018) [Unconjugated]
Intracellular Staining by Flow Cytometry IL-17D Antibody (246018) [Unconjugated]
Species: Hu
Applications: CyTOF-ready, IHC, ICFlow, WB
IL-17RD/SEF
Antibody
AF2275
Immunohistochemistry IL-17RD/SEF Antibody
Flow Cytometry IL-17RD/SEF Antibody
(1 Review)
(2 Publications)
Species: Hu
Applications: CyTOF-ready, Flow, IHC, WB
TRAF-6 Inhibitor
Peptide Set
NBP2-26506
Unknown TRAF-6 Inhibitor Peptide Set
(19 Publications)
Species: Hu, Mu, Rt
Applications: B/N, In vitro
CCL2/JE/MCP-1 [HRP]
DCP00
N/A CCL2/JE/MCP-1 [HRP]
N/A CCL2/JE/MCP-1 [HRP]
N/A CCL2/JE/MCP-1 [HRP]
(254 Publications)
Species: Hu
Applications: ELISA
CXCL1/GRO
alpha/KC/CINC-1 [Biot
DY453
N/A CXCL1/GRO alpha/KC/CINC-1 [Biotin]
(288 Publications)
Species: Mu
Applications: ELISA
ERK2 Antibody
[Unconjugated]
AF1230
Western Blot ERK2 Antibody [Unconjugated]
Immunohistochemistry ERK2 Antibody [Unconjugated]
Knockout Validated ERK2 Antibody [Unconjugated]
(3 Publications)
Species: Hu, Mu, Rt
Applications: IHC, KO, WB
NFkB p105/p50
Antibody (2J10D7) - B ...
NB100-56583
Flow Cytometry NFkB p105/p50 Antibody (2J10D7) - BSA Free
Flow Cytometry NFkB p105/p50 Antibody (2J10D7) - BSA Free
Flow Cytometry NFkB p105/p50 Antibody (2J10D7) - BSA Free
(1 Review)
(5 Publications)
Species: Hu, Rb, Rt
Applications: Flow, IHC, IHC-P, KO, WB
IL-17C Antibody
(177114) [Unconjugate
MAB1234
Intracellular Staining by Flow Cytometry IL-17C Antibody (177114) [Unconjugated]
Immunohistochemistry IL-17C Antibody (177114) [Unconjugated]
(2 Publications)
Species: Hu
Applications: CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta), IHC, ICFlow, WB

Publications for IL-17RA/IL-17R (177-IR)(4)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, FRET, In Vivo, Surface Plasmon Resonance.


Filter By Application
Bioassay
(1)
FRET
(1)
In Vivo
(1)
Surface Plasmon Resonance
(1)
All Applications
Filter By Species
Human
(3)
Mouse
(1)
All Species

Reviews for IL-17RA/IL-17R (177-IR) (0)

There are no reviews for IL-17RA/IL-17R (177-IR). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for IL-17RA/IL-17R (177-IR) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional IL-17RA/IL-17R Products

Blogs on IL-17RA/IL-17R

There are no specific blogs for IL-17RA/IL-17R, but you can read our latest blog posts.
Read our latest blog and use the new citation tool on bio-techne.com

Customers Who Bought This Also Bought

1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.
TNF-alpha [Unconjugated]
210-TA-005

Contact Information

Product PDFs

  PDF SDS
  PDF Datasheet
  Request CofA

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF and receive a gift card or discount.


Bioinformatics

Gene Symbol IL17RA
Uniprot