Recombinant Human CD44v5 Fc Chimera Avi-tag Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD44, also known as extracellular matrix receptor III (ECMRIII), is a non-kinase transmembrane glycoprotein that regulates numerous functions including cell proliferation, adhesion, migration, hematopoiesis, and lymphocyte activation. Mature human CD44 consists of an extracellular domain (ECD) with a hyaluronan‑binding, disulfide-stabilized link region and a stem region, a transmembrane domain, and a cytoplasmic domain. The full-length ECD of human CD44 shares 63% amino acid sequence identity with mouse CD44. In humans, CD44 is encoded by 19 exons with 10 constant in all isoforms. The standard form of CD44 (CD44s) is encoded by the 10 constant exons and is the shortest and most abundantly expressed isoform. The remaining 9, variant exons of CD44 can undergo complex alternative splicing and are expressed in a cell-specific manner and in the pathophysiology of many diseases. The N-terminal ECD of CD44 contains a binding site for Hyaluronan (HA), the most common ligand of CD44. CD44 exhibits multiple different functions and is aberrantly up-regulated among diverse tumors. It can bind HA and function as a "platform" for growth factors and metalloproteinases. CD44 can function as a co-receptor that modifies activity of receptors including MET and the ERBB family of tyrosine kinases. Further, CD44 can link the plasma membrane to the actin cytoskeleton via the ERM. CD44 has been found to bind E- and L-selectin on tumor cells and E-selectin on neutrophils. Additionally, distinct variants of CD44 have been found to interact with LSECtin and potentially mediate its function in the immune system. Human CD44v5 contains exon 10 and is associated with tumor progression and metastasis in many cancer types and is considered a functional cancer biomarker. Our Avi-tag Biotinylated CD44 features biotinylation at a single site contained within the Avi-tag, a unique 15 amino acid peptide. Protein orientation will be uniform when bound to streptavidin-coated surface due to the precise control of biotinylation and the rest of the protein is unchanged so there is no interference in the protein's bioactivity.

Array AVI10146

• CD44 Antibodies
• CD44 Antibody Pair
• CD44 ELISA Kits
• CD44 Lysates
• CD44 Protein
• CD44 ELISA
• CD44 Proteins and Enzymes