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PTPRN2 Antibody

Images

 
Western Blot: PTPRN2 Antibody [NBP1-81628] - Analysis in human cell line U-87 MG.
Immunocytochemistry/ Immunofluorescence: PTPRN2 Antibody [NBP1-81628] - Staining of human cell line AF22 shows localization to vesicles. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: PTPRN2 Antibody [NBP1-81628] - Staining of human liver shows strong cytoplasmic positivity in bile duct cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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PTPRN2 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: QDDDDRLYQEVHRLSATLGGLLQDHGSRLLPGALPFARPLDMERKKSEHPESSLSSEEETAGVENVKSQTYSKDLLGQQPHSEPGAAAFGELQNQMPGPSKEEQSLPAGAQ
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTPRN2
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation/Permeabilization: PFA/Triton X-100.
Control Peptide
PTPRN2 Recombinant Protein Antigen (NBP1-81628PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for PTPRN2 Antibody

  • EC 3.1.3.48
  • IA-2beta
  • IAR/receptor-like protein-tyrosine phosphatase
  • ICAARIARPTPRP
  • Islet cell autoantigen-related protein
  • KIAA0387
  • phogrin
  • protein tyrosine phosphatase receptor pi
  • protein tyrosine phosphatase, receptor type, N polypeptide 2
  • receptor-type tyrosine-protein phosphatase N2
  • R-PTP-N2
  • tyrosine phosphatase IA-2 beta

Background

PTPRN2 is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PTPRN2