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PPAR gamma/NR1C3 Antibody (A3409A) [Unconjugated]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP, GS
Clone
A3409A
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Suitable Sample Type
23005

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PPAR gamma/NR1C3 Antibody (A3409A) [Unconjugated] Summary

Immunogen
Recombinant human PPAR gamma/NR1C3
Amino Acids 3-108
Specificity
This antibody specifically recognizes human PPAR gamma 1 and gamma 2 and cross-reacts with mouse and rat PPAR gamma 1 and gamma 2. This antibody does not recognize human PPAR alpha and PPARδ. Not yet tested in other species.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
PPARG
Purity Statement
Protein A or G purified from ascites
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunohistochemistry
  • Immunoprecipitation
  • Gel Supershift Assay
Publications
Read Publication using
PP-A3409A-00 in the following applications:

Packaging, Storage & Formulations

Storage
This antibody is stable for greater than six months when held at -20° C in a manual defrost freezer or at -70° C. Upon thawing, the antibody can be stored at 2° - 8° C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Buffer
A liquid formulation in physiologic saline with 0.1% NaN3.
Preservative
0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PPAR gamma/NR1C3 Antibody (A3409A) [Unconjugated]

  • CIMT1
  • NR1C3
  • NR1C3GLM1
  • Nuclear receptor subfamily 1 group C member 3
  • peroxisome proliferator-activated receptor gamma 1
  • peroxisome proliferator-activated receptor gamma
  • PPAR gamma
  • PPARG
  • PPARG1peroxisome proliferative activated receptor, gamma
  • PPARG2PPARgamma
  • PPAR-gamma

Background

Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma ; NR1C3) is a member of the orphan nuclear receptor family. Oxidized metabolites of linoleic acid, 9-hydroxyctadienoic acid (9-HODE) and 13-HODE are activators and ligands of PPAR gamma. PPAR gamma is expressed in white adipose tissue, intestinal mucosa, colon, spleen, monocytes, macrophages, retina, cartilage, osteoclasts, and skeletal muscle. PPAR gamma plays important roles in lipid and glucose metabolism and has been implicated in obesity-related metabolic diseases such as hyperlipidemia, insulin resistance, and coronary artery disease. Three known family members are called PPAR alpha, δ, and gamma. Three N-terminal isoforms, called gamma 1, gamma 2 and gamma 3, are known to arise by alternative splicing and promoter usage from the PPAR gamma gene. RXR is an obligate partner for PPAR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PPAR gamma/NR1C3 Antibody (PP-A3409A-00)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Proximity Ligation Assay (PLA).


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Bioinformatics

Gene Symbol PPARG