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Potassium Channel Kv3.1 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cell line U-2 OS shows localization to nucleus, nuclear membrane and cytosol. Antibody staining shown in green.
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human kidney shows no positivity in cells in tubules as expected.
Orthogonal Strategies: Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Analysis in human cerebral cortex and kidney tissues. Corresponding KCNC1 RNA-seq data are presented for the ...read more
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human small intestine shows no positivity in glandular cells as expected.
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cerebellum shows moderate to strong cytoplasmic positivity in granular layer.
Immunohistochemistry-Paraffin: Potassium Channel Kv3.1 Antibody [NBP2-30395] - Staining of human cerebral cortex shows weak to moderate cytoplasmic positivity in neurons.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Validated by:
       

Orthogonal Strategies

 

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Potassium Channel Kv3.1 Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to amino acids: EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDS
Predicted Species
Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNC1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:500 - 1:1000
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Control Peptide
Potassium Channel Kv3.1 Protein (NBP2-30395PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for Potassium Channel Kv3.1 Antibody

  • FLJ41162
  • FLJ42249
  • FLJ43491
  • KCNC1
  • KV3.1
  • KV4
  • MGC129855
  • NGK2
  • Potassium Channel Kv3.1
  • potassium voltage-gated channel subfamily C member 1
  • potassium voltage-gated channel, Shaw-related subfamily, member 1
  • voltage-gated potassium channel protein KV3.1
  • Voltage-gated potassium channel subunit Kv3.1
  • Voltage-gated potassium channel subunit Kv4

Background

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNC1
Uniprot