| Description | Biological Activity: ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke. Technical Data: M.Wt:259.33 Formula:C13H13N3OS Solubility:Soluble to 30 mM in DMSO and to 15 mM in ethanol with gentle warming Purity:>99 % CAS No:4311-88-0 |
| Storage | Store at RT |
