LAMC2 Antibody (CL2980)

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: IF/IHC, IHC-P, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-42388	Applications	Species
Gavish A, Tyler M, Greenwald AC et al. Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours Nature 2023-06-01 [PMID: 37258682]
Ravillah D, Kieber-Emmons AL, Singh S et al. Discovery and Initial Characterization of Long Intergenic Non-coding RNAs Associated with Esophageal Adenocarcinoma Gastroenterology 2023-05-12 [PMID: 37182784] (WB)	WB
Parikh AS, Puram SV, Faquin WC et al. Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis Oral Oncol. 2019-11-05 [PMID: 31704557] (IHC-P, IF/IHC, Human)	IHC-P, IF/IHC	Human
Puram Sidharth V, Tirosh Itay, Parikh Anuraag S et al. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer. Cell 2018-12-14 [PMID: 29198524] (IF/IHC, Human)	IF/IHC	Human

Array NBP2-42388

• LAMC2 Antibodies
• LAMC2 Lysates
• LAMC2 Proteins