Human Pro-BDNF DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

BDNF (Brain-Derived Neurotrophic Factor) is a secreted protein that regulates many aspects of neuronal development and function in the nervous system. It is produced as proBDNF in response to neuronal activity or inflammatory stimulation and is then cleaved before associating into a homodimer. It is expressed throughout the nervous system as well as by fibroblasts, megakaryocytes/platelets, and smooth muscle cells. BDNF regulates neural stem cell survival and differentiation, axon/dendrite differentiation, synapse formation and maturation, and refinement of developing circuits. It is also a key regulator of synaptic plasticity and late-phase long-term potentiation. BDNF signals through the TrkB and NGF R/TNFRSF16 receptors. Secreted proBDNF can bind to NGF R/TNFRSF16 and induce long-term depression and cell apoptosis.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using DY3175	Applications	Species
Li, H;Zhao, M;Jiang, C;Zhao, H;Wu, C;Li, Y;Zhang, S;Xu, P;Mou, T;Xu, Y;Huang, M; Elevated Plasma Levels of Mature Brain-Derived Neurotrophic Factor in Major Depressive Disorder Patients with Higher Suicidal Ideation Brain sciences 2023-08-21 [PMID: 37626579] (Human)		Human
Bang-Kittilsen, G;Egeland, J;Ueland, T;Andersen, E;Bigseth, TT;Holmen, TL;Mordal, J;Holst, R;Engh, JA; The relationship between the brain-derived neurotrophic factor and neurocognitive response to physical exercise in individuals with schizophrenia Psychoneuroendocrinology 2023-08-03 [PMID: 37562099] (Human)		Human
Nilsson, J;Ekblom, M;Moberg, M;Lövdén, M; The role of acute changes in mBDNF, cortisol and pro-BDNF in predicting cognitive performance in old age Scientific reports 2023-06-09 [PMID: 37296176] (Human)		Human
I Marmouzi, S Myers, DJ Buck, RL Davis, HR Arias alpha7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms The international journal of biochemistry & cell biology, 2023-03-24;158(0):106405. 2023-03-24 [PMID: 36966906] (Mouse)		Mouse
MLA Robinson-A, B Michalski, B Vidal-Mart, LR Hernández, MW Santiesteb, M Fahnestock BDNF, proBDNF and IGF-1 serum levels in na�ve and medicated subjects with autism Scientific Reports, 2022-08-12;12(1):13768. 2022-08-12 [PMID: 35962006] (Human)		Human
G Riolo, C Ricci, N De Angelis, C Marzocchi, G Guerrera, G Borsellino, F Giannini, S Battistini BDNF and Pro-BDNF in Amyotrophic Lateral Sclerosis: A New Perspective for Biomarkers of Neurodegeneration Brain sciences, 2022-05-09;12(5):. 2022-05-09 [PMID: 35625004] (Human)		Human
W Zwoli?ska, M Skibinska, A S?opie?, M Dmitrzak-W ProBDNF as an Indicator of Improvement among Women with Depressive Episodes Metabolites, 2022-04-16;12(4):. 2022-04-16 [PMID: 35448545] (Human)		Human
C Wu, J Lu, S Lu, M Huang, Y Xu Increased ratio of mature BDNF to precursor-BDNF in patients with major depressive disorder with severe anhedonia J Psychiatr Res, 2020-05-12;126(0):92-97. 2020-05-12 [PMID: 32428748] (Human)		Human
J Benicky, M Sanda, Z Brnakova K, R Goldman N-Glycosylation is required for secretion of the precursor to brain-derived neurotrophic factor (proBDNF) carrying sulfated LacdiNAc structures J. Biol. Chem., 2019-09-26;0(0):. 2019-09-26 [PMID: 31558607] (Rat)		Rat
J Wang, Y Chen, C Zhang, Z Xiang, J Ding, X Han Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR J. Hazard. Mater., 2019-03-26;373(0):504-518. 2019-03-26 [PMID: 30947040] (Mouse)		Mouse
H Jiang, S Chen, C Li, N Lu, Y Yue, Y Yin, Y Zhang, X Zhi, D Zhang, Y Yuan The serum protein levels of the tPA-BDNF pathway are implicated in depression and antidepressant treatment Transl Psychiatry, 2017-04-04;7(4):e1079. 2017-04-04 [PMID: 28375203] (Human)		Human
Cynthia Azeredo Cordeiro Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis Braz J Infect Dis, 2016-12-05;0(0):. 2016-12-05 [PMID: 27932287] (Human)		Human
Show All 12 Publications. Collapse Publications.

Array DY3175

• BDNF Antibodies
• BDNF ELISA Kits
• BDNF Lysates
• BDNF Proteins
• BDNF ELISAs
• BDNF Proteins and Enzymes