Human Myeloperoxidase Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide dependent formation of hypochlorus acid (HOCl) and other reactive species. Enzymatically active MPO is a disulfide-linked tetramer that contains two heme groups and two copies each of the heavy and light chains. MPO binds Albumin, MMR, Cytokeratin 1 on vascular endothelial cells, HMW Kininogen, and Integrin CD11b/CD18 on neutrophils. These interactions promote MPO clearance, a reduction of nitric oxide and bradykinin levels, reduced vasodilation, and continued neutrophil activation. Neutrophil MPO is stored in cytoplasmic azurophilic granules. Upon cellular activation and degranulation, MPO is delivered into phagosomes where it is required for the killing of phagocytosed bacteria. Activated neutrophils also release granule contents extracellularly. Elevated plasma MPO levels have been associated with a variety of clinical conditions including systemic inflammation, eclampsia, risk of cardiovascular events, vascular endothelial dysfunction, severity of multiple sclerosis, and prospective mortality and oxidative stress during hemodialysis.

We have publications tested in 2 confirmed species: Human, Mouse.

Showing Publications 1 - 10 of 37. Show All 37 Publications. Collapse Publications.

Publications using DMYE00B	Applications	Species
Borowiec, A;Ozdowska, P;Rosinska, M;Jagiello-Gruszfeld, A;Jasek, S;Waniewska, J;Kotowicz, B;Kosela-Paterczyk, H;Lampka, E;Makowka, A;Fuksiewicz, M;Chojnacka, M;Zebrowska, A;Gepner, K;Kapala, A;Cieszanowski, A;Nowecki, Z;Walewski, J; Prognostic value of coronary atherosclerosis and CAC score for the risk of chemotherapy-related cardiac dysfunction (CTRCD): The protocol of ANTEC study PloS one 2023-08-17 [PMID: 37590267] (Human)		Human
Al Asmari, AK;Al Shehri, HA;Khan, HA;Al Omani, S;Kadasah, SG;Horaib, GB;Al Buraidi, A;Al Sharif, AA;Mohammed, FS;Abbasmanthiri, R;Osman, NM; Serum Levels of Proinflammatory Biomarkers in Military Recruits with and without Metabolic Syndrome Mediators of inflammation 2023-04-30 [PMID: 37168278] (Human)		Human
B Kasztelan-, B Zygo, A Rycyk-Boja, A Surdacka, J Rolinski, H Cichoz-Lac Blood concentrations of mediators released from activated neutrophils are related to the severity of alcohol-induced liver damage PLoS ONE, 2023-01-06;18(1):e0280068. 2023-01-06 [PMID: 36607987] (Human)		Human
L Morimont, M Dechamps, C David, C Bouvy, C Gillot, H Haguet, J Favresse, L Ronvaux, J Candiracci, M Herzog, PF Laterre, J De Poorter, S Horman, C Beauloye, J Douxfils NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study Biomolecules, 2022-07-27;12(8):. 2022-07-27 [PMID: 36008932] (Human)		Human
S Kongkiatka, L Terkawi, Y Guan, V Adema, M Hasipek, T Dombrovski, M Co, W Walter, H Awada, Y Parker, S Hutter, S Pagliuca, C Gurnari, HJ Rogers, M Meggendorf, DJ Lindner, T Haferlach, V Visconte, T LaFrambois, BK Jha, JP Maciejewsk Rare germline alterations of myeloperoxidase predispose to myeloid neoplasms Leukemia, 2022-06-27;0(0):. 2022-06-27 [PMID: 35761024] (Human)		Human
BM Henry, MHS de Oliveir, I Cheruiyot, J Benoit, J Rose, EJ Favaloro, G Lippi, S Benoit, N Pode Shakk Cell-Free DNA, Neutrophil extracellular traps (NETs), and Endothelial Injury in Coronavirus Disease 2019- (COVID-19-) Associated Acute Kidney Injury Mediators of Inflammation, 2022-04-22;2022(0):9339411. 2022-04-22 [PMID: 35497096] (Human)		Human
A Brandau, N Ibrahim, J Klopf, H Hayden, M Ozsvar-Koz, T Afonyushki, S Bleichert, L Fuchs, V Watzinger, V Nairz, E Manville, V Kessler, H Stangl, W Eilenberg, C Neumayer, C Brostjan Association of Lipoproteins with Neutrophil Extracellular Traps in Patients with Abdominal Aortic Aneurysm Biomedicines, 2022-01-20;10(2):. 2022-01-20 [PMID: 35203427] (Human)		Human
V Schimek, K Strasser, A Beer, S Göber, N Walterskir, C Brostjan, C Müller, T Bachleitne, M Bergmann, H Dolznig, R Oehler Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment Cell Death & Disease, 2022-02-04;13(2):113. 2022-02-04 [PMID: 35121727] (Human)		Human
A Malézieux-, L Azurmendi, S Pagano, N Vuilleumie, JC Sanchez, D Zekry, JL Reny, J Stirnemann, N Garin, V Prendki, On Behalf Role of Clinical Characteristics and Biomarkers at Admission to Predict One-Year Mortality in Elderly Patients with Pneumonia Journal of Clinical Medicine, 2021-12-25;11(1):. 2021-12-25 [PMID: 35011845] (Human)		Human
C Gar, B Thorand, C Herder, C Sujana, M Heier, C Meisinger, A Peters, W Koenig, W Rathmann, M Roden, M Stumvoll, H Maalmi, T Meitinger, H Then, J Seissler, C Then Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study PLoS ONE, 2022-01-06;17(1):e0262330. 2022-01-06 [PMID: 34990470] (Human)		Human
M Garley, D Dziemia?cz, W Ratajczak-, A Pryczynicz, K Nowak, B ?azarczyk, E Jab?o?ska NETs biomarkers in saliva and serum OSCC patients: One hypothesis, two conclusions Advances in medical sciences, 2021-12-28;67(1):45-54. 2021-12-28 [PMID: 34971930] (Human)		Human
S Roumelioti, A Veljkovic, PI Georgianos, G Lazarevic, Z Perisic, J Hadzi-Djok, V Liakopoulo, G Kocic Association between Biomarkers of Oxidative Stress and Inflammation with Cardiac Necrosis and Heart Failure in Non-ST Segment Elevation Myocardial Infarction Patients and Various Degrees of Kidney Function Oxidative Medicine and Cellular Longevity, 2021-11-01;2021(0):3090120. 2021-11-01 [PMID: 34760045] (Human)		Human
H Hayden, N Ibrahim, J Klopf, B Zagrapan, LM Mauracher, L Hell, TM Hofbauer, AS Ondracek, C Schoergenh, B Jilma, IM Lang, I Pabinger, W Eilenberg, C Neumayer, C Brostjan ELISA detection of MPO-DNA complexes in human plasma is error-prone and yields limited information on neutrophil extracellular traps formed in vivo PLoS ONE, 2021-04-22;16(4):e0250265. 2021-04-22 [PMID: 33886636] (Human)		Human
AE Charkiewic, M Garley, W Ratajczak-, K Nowak, E Jab?o?ska, D Ma?lach, WJ Omeljaniuk Profile of new vascular damage biomarkers in middle-aged men with arterial hypertension Advances in medical sciences, 2021-03-05;66(1):185-191. 2021-03-05 [PMID: 33684644] (Human)		Human
K Singh, AC Kwong, H Madarati, S Kunasekara, T Sparring, AE Fox-Robich, PC Liaw, CA Kretz Characterization of ADAMTS13 and von Willebrand factor levels in septic and non-septic ICU patients PLoS ONE, 2021-02-19;16(2):e0247017. 2021-02-19 [PMID: 33606732] (Human)		Human
N Kashiwagi, F Saito, H Maegawa, K Kaneda Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo results Cytokine, 2021-01-01;139(0):155410. 2021-01-01 [PMID: 33395614] (Human)		Human
SA Harper, JR Bassler, S Peramsetty, Y Yang, LM Roberts, D Drummer, RT Mankowski, C Leeuwenbur, K Ricart, RP Patel, MM Bamman, SD Anton, BC Jaeger, TW Buford Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial Exp Gerontol, 2020-10-15;0(0):111111. 2020-10-15 [PMID: 33068691] (Human)		Human
SF Hughes, AJ Moyes, RM Lamb, P Ella-Tongw, C Bell, A Moussa, I Shergill The role of specific biomarkers, as predictors of post-operative complications following flexible ureterorenoscopy (FURS), for the treatment of kidney stones: a single-centre observational clinical pilot-study in 37 patients BMC Urol, 2020-08-14;20(1):122. 2020-08-14 [PMID: 32795278] (Human)		Human
WJ Omeljaniuk, E Jab?o?ska, M Garley, A Pryczynicz, W Ratajczak-, K Socha, MH Borawska, AE Charkiewic Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried Sci Rep, 2020-08-04;10(1):13088. 2020-08-04 [PMID: 32753622] (Human)		Human
P Maréchal, J Tridetti, ML Nguyen, O Wéra, Z Jiang, M Gustin, AF Donneau, C Oury, P Lancellott Neutrophil Phenotypes in Coronary Artery Disease J Clin Med, 2020-05-25;9(5):. 2020-05-25 [PMID: 32466264] (Human)		Human
J Perdomo, HHL Leung, Z Ahmadi, F Yan, JJH Chong, FH Passam, BH Chong Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia Nat Commun, 2019-03-21;10(1):1322. 2019-03-21 [PMID: 30899022] (Human)		Human
JR Grunwell, VD Giacalone, S Stephenson, C Margaroli, BS Dobosh, MR Brown, AM Fitzpatric, R Tirouvanzi Neutrophil Dysfunction in the Airways of Children with Acute Respiratory Failure Due to Lower Respiratory Tract Viral and Bacterial Coinfections Sci Rep, 2019-02-27;9(1):2874. 2019-02-27 [PMID: 30814584] (Human)		Human
JA Luetkens, AC Wolpers, T Beiert, D Kuetting, D Dabir, R Homsi, H Meenderman, NA Dayé, V Knappe, M Karsdal, SH Nielsen, F Genovese, F Stöckigt, M Linhart, D Thomas, G Nickenig, HH Schild, JW Schrickel, RP Andrié Cardiac magnetic resonance using late gadolinium enhancement and atrial T1 mapping predicts poor outcome in patients with atrial fibrillation after catheter ablation therapy Sci Rep, 2018-09-11;8(1):13618. 2018-09-11 [PMID: 30206274] (Human)		Human
E Kimak, B Zi?ba, D Duma, J Solski Myeloperoxidase level and inflammatory markers and lipid and lipoprotein parameters in stable coronary artery disease Lipids Health Dis, 2018-04-04;17(1):71. 2018-04-04 [PMID: 29618370] (Human)		Human
C Thålin, S Lundström, C Seignez, M Daleskog, A Lundström, P Henriksson, T Helleday, M Phillipson, H Wallén, M Demers Citrullinated histone H3 as a novel prognostic blood marker in patients with advanced cancer PLoS ONE, 2018-01-11;13(1):e0191231. 2018-01-11 [PMID: 29324871] (Human)		Human
A Szentpéter, N Zsíros, VE Varga, H L?rincz, M Katkó, I Seres, P Fülöp, G Paragh, M Harangi Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia VASA, 2017-06-12;0(0):1-7. 2017-06-12 [PMID: 28602123] (Human)		Human
S Chandran, J Watkins, A Abdul-Aziz, M Shafat, PA Calvert, KM Bowles, MD Flather, SA Rushworth, AD Ryding Inflammatory Differences in Plaque Erosion and Rupture in Patients With ST-Segment Elevation Myocardial Infarction J Am Heart Assoc, 2017-05-03;6(5):. 2017-05-03 [PMID: 28468787] (Human)		Human
FA Piedra, M Mei, V Avadhanula, R Mehta, L Aideyan, RP Garofalo, PA Piedra The interdependencies of viral load, the innate immune response, and clinical outcome in children presenting to the emergency department with respiratory syncytial virus-associated bronchiolitis PLoS ONE, 2017-03-07;12(3):e0172953. 2017-03-07 [PMID: 28267794] (Human)		Human
CW Ong, PJ Pabisiak, S Brilha, P Singh, F Roncaroli, PT Elkington, JS Friedland Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis J Neuroinflammation, 2017-02-07;14(1):31. 2017-02-07 [PMID: 28173836] (Human)		Human
Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through ?7nAChR-dependent JAK2-STAT3 signaling Sci Rep, 2016-11-22;6(0):37709. 2016-11-22 [PMID: 27874086] (Mouse)		Mouse
Singh R, Mackay A, Patel A, Garcha D, Kowlessar B, Brill S, Donnelly L, Barnes P, Donaldson G, Wedzicha J Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease. Respir Res, 2014-09-14;15(0):114. 2014-09-14 [PMID: 25218165] (Human)		Human
Kahli A, Guenancia C, Zeller M, Grosjean S, Stamboul K, Rochette L, Girard C, Vergely C Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. PLoS ONE, 2014-08-29;9(8):e105759. 2014-08-29 [PMID: 25171167] (Human)		Human
Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris. PLoS ONE, 2011-04-29;6(4):e19340. 2011-04-29 [PMID: 21559401] (Human)		Human
Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma. J. Allergy Clin. Immunol., 2010-11-01;126(5):962. 2010-11-01 [PMID: 20810157] (Human)		Human
Tziakas DN, Chalikias GK, Tentes IK, Stakos D, Chatzikyriakou SV, Mitrousi K, Kortsaris AX, Kaski JC, Boudoulas H Interleukin-8 is increased in the membrane of circulating erythrocytes in patients with acute coronary syndrome. Eur. Heart J., 2008-09-02;29(22):2713-22. 2008-09-02 [PMID: 18765457] (Human)		Human
Hothersall EJ, Chaudhuri R, McSharry C, Donnelly I, Lafferty J, McMahon AD, Weir CJ, Meiklejohn J, Sattar N, McInnes I, Wood S, Thomson NC Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma. Thorax, 2008-08-29;63(12):1070-5. 2008-08-29 [PMID: 18757458] (Human)		Human
Miller M, Ramsdell J, Friedman PJ, Cho JY, Renvall M, Broide DH Computed tomographic scan-diagnosed chronic obstructive pulmonary disease-emphysema: eotaxin-1 is associated with bronchodilator response and extent of emphysema. J. Allergy Clin. Immunol., 2007-11-01;120(5):1118-25. 2007-11-01 [PMID: 17983873] (Human)		Human
Show All 37 Publications. Collapse Publications.

Array DMYE00B

• Myeloperoxidase/MPO Antibodies
• Myeloperoxidase/MPO Kits
• Myeloperoxidase/MPO Lysate
• Myeloperoxidase/MPO Proteins
• Myeloperoxidase/MPO ELISAs
• Myeloperoxidase/MPO Proteins and Enzymes