CFTR Antibody (CF3)

Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S.typhi intestinal submucosal uptake.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Chicken, Golden Syrian Hamster.

We have publications tested in 4 applications: FLOW, ICC/IF, IF/IHC, WB.

Showing Publications 1 - 10 of 15. Show All 15 Publications. Collapse Publications.

Publications using NB300-511	Applications	Species
Mizoguchi M, Takemori H, Furukawa S et al. Increased expression of glucagon-like peptide-1 and cystic fibrosis transmembrane conductance regulator in the ileum and colon in mouse treated with metformin Endocrine journal 2022-10-05 [PMID: 36198615] (WB, Human)	WB	Human
Lu LY, Pan N, Huang ZH et al. CFTR Suppresses Neointimal Formation Through Attenuating Proliferation and Migration of Aortic Smooth Muscle Cells Journal of Cardiovascular Pharmacology 2022-06-01 [PMID: 35266910] (WB)	WB
Di Fulvio M, Bogdani M, Velasco M et al. Heterogeneous expression of CFTR in insulin-secreting beta-cells of the normal human islet PloS one 2020-12-02 [PMID: 33264332] (ICC/IF, Human)	ICC/IF	Human
Marozkina N, Bosch J, Cotton C et al. Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium American Journal of Physiology-Lung Cellular and Molecular Physiology 2019-08-01 [PMID: 31116581] (WB)	WB
Ye R, Onodera T, Blanchard PG et al. b1 syntrophin supports autophagy initiation and protects against cerulein-induced acute pancreatitis. Am. J. Pathol. 2019-01-14 [PMID: 30653956] (WB, Mouse)	WB	Mouse
Romani L, Oikonomou V, Moretti S et al. Thymosin alpha1 represents a potential potent single-molecule-based therapy for cystic fibrosis. Nat. Med. 2017-04-10 [PMID: 28394330] (IF/IHC, Mouse)	IF/IHC	Mouse
Meissner A, Yang J et al. Tumor necrosis factor-alplha-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. Circulation 2012-05-06 [PMID: 22534621] (WB, Golden Syrian Hamster)	WB	Golden Syrian Hamster
Rottner M et al. Exaggerated apoptosis and NF-kappaB activation in pancreatic and tracheal cystic fibrosis cells. FASEB J;21(11):2939-48. 2007-09-01 [PMID: 17442732] (WB, Human)	WB	Human
Kulka M et al. Differential regulation of cystic fibrosis transmembrane conductance regulator by interferon gamma in mast cells and epithelial cells. J Pharmacol Exp Ther;315(2):563-70. 2005-11-01 [PMID: 16051699] (ICC/IF, Rat, Human)	ICC/IF	Rat, Human
Benlloch, M et al. Acceleration of glutathione efflux inhibition of gamma glutamyl transpeptidase sensitize metastic B16 melanoma cells to endothelium-induced cytotoxicity. J Biol Chem 280(8): 6950-6959. 2005-01-01 [PMID: 15561710]
Dalby-Payne JR et al. Polarization of specific tropomyosin isoforms in gastrointestinal epithelial cells and their impact on CFTR at the apical surface. Mol Biol Cell;14(11):4365-75. 2003-11-01 [PMID: 12960432] (IF/IHC, WB, Human)	IF/IHC, WB	Human
Laverty G et al. PTH stimulates a Cl(-)-dependent and EIPA-sensitive current in chick proximal tubule cells in culture. Am J Physiol Renal Physiol;284(5):F987-95. 2003-05-01 [PMID: 12505864] (WB, Chicken)	WB	Chicken
Kulka M, Gilchrist M, Duszyk M, Befus AD. Expression and functional characterization of CFTR in mast cells. J Leukoc Biol;71(1):54-64. 2002-01-01 [PMID: 11781380] (FLOW, ICC/IF, Rat, Human)	FLOW, ICC/IF	Rat, Human
Pier GB et al. Salmonella typhi uses CFTR to enter intestinal epithelial cells. Nature;393(6680):79-82. 1998-05-07 [PMID: 9590693] (WB, Mouse, Human)	WB	Mouse, Human
Walker J et al. Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related proteins. J Cell Sci;108 ( Pt 6)():2433-44. 1995-06-01 [PMID: 7545688] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Show All 15 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: James Xiao	Flow	Human	09/30/2020	View Summary Application Flow Cytometry Sample Tested human airway epithelial cells Species Human Lot UB278823
Enlarge	5 reviewed by: Verified Customer	IF		05/09/2014	View Summary Application Immunofluorescence Lot NK179310

Array NB300-511

• CFTR Antibodies
• CFTR ELISA Kit
• CFTR Proteins