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CD46 Antibody (344519) [CoraFluor™ 1]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, CyTOF-ready
Clone
344519
Clonality
Monoclonal
Host
Mouse
Conjugate
CoraFluor 1

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
FAB2005U-100UG
Alexa Fluor 405
FAB2005V-100UG
Alexa Fluor 488
FAB2005G-100UG
Alexa Fluor 532
FAB2005X
Alexa Fluor 594
FAB2005T-100UG
Alexa Fluor 647
FAB2005R-100UG
Alexa Fluor 700
FAB2005N-100UG
Alexa Fluor 750
FAB2005S-100UG
Allophycocyanin/Cy7
FAB2005APCCY7
Biotin
FAB2005B
DyLight 350
FAB2005D
DyLight 405
FAB2005E
DyLight 488
FAB2005K
DyLight 550
FAB2005L
DyLight 594
FAB2005M
DyLight 650
FAB2005W
DyLight 680
FAB2005Y
DyLight 755
FAB2005Z
FITC
FAB2005F
HRP
FAB2005H
Janelia Fluor 525
FAB2005JF525
Janelia Fluor 549
FAB2005I
Janelia Fluor 585
FAB2005JF585
Janelia Fluor 635
FAB2005JF635
Janelia Fluor 646
FAB2005J
Janelia Fluor 669
FAB2005JF669
PE/Atto594
FAB2005PEATT594
PE/Cy5.5
FAB2005PECY55
PE/Cy7
FAB2005PECY7
PerCP
FAB2005C
Unconjugated
MAB2005
mFluor Violet 450 SE
FAB2005MFV450
mFluor Violet 500 SE
FAB2005MFV500
mFluor Violet 610 SE
FAB2005MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
MAB2005
Carrier Free
MAB2005
Carrier Free
MAB2005-SP
Carrier Free
FAB2005V-100UG
Carrier Free
FAB2005U-100UG
Carrier Free
FAB2005T-100UG
Carrier Free
FAB2005S-100UG
Carrier Free
FAB2005R-100UG
Carrier Free
FAB2005N-100UG
Carrier Free
FAB2005G-100UG
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CD46 Antibody (344519) [CoraFluor™ 1] Summary

Description
CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
Immunogen
Mouse myeloma cell line NS0-derived recombinant human CD46
Cys35-Asp328
Accession # NP_722548
Specificity
Detects human CD46 in direct ELISAs and Western blots.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
CD46
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark. Do not freeze.
Buffer
PBS
Preservative
No Preservative
Purity
Protein A or G purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for CD46 Antibody (344519) [CoraFluor™ 1]

  • AHUS2
  • CD46 antigen
  • CD46 molecule, complement regulatory protein
  • CD46
  • MCP
  • membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)
  • MIC10
  • TLXcomplement regulatory protein
  • trophoblast leucocyte common antigen
  • Trophoblast leukocyte common antigen
  • trophoblast-lymphocyte cross-reactive antigen

Background

CD46 is one of the membrane complement regulatory proteins. CD46 possesses C3b-binding and factor I cofactor activities which play important roles in regulation of complement activation pathway. CD46 is widely distributed on blood cells, endothelial cells, epithelial cells and tumor cell lines. CD46 exists as many isoforms in a variety of tissues. The antigen has a broad distribution and is present on leukocytes, platelets, endothelial cells, epithelial cells and fibroblasts. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. It is expressed on thymocytes, B cells, monocytes, granulocytes, NK cells, platelets, epithelial and endothelial cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol CD46