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Caspase-11 Antibody (8A5) [DyLight 755]

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Product Details

Summary
Reactivity Mu, RtSpecies Glossary
Applications WB, ELISA, Flow, IP
Clone
8A5
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 755

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Caspase-11 Antibody (8A5) [DyLight 755] Summary

Immunogen
Recombinant mouse caspase-11 (p20 fragment).
Specificity
Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Rat
Gene
Casp4
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunoprecipitation
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Caspase-11 Antibody (8A5) [DyLight 755]

  • ich-3
  • CASP11
  • CASP-11
  • CASP4
  • CASP-4
  • caspase 4, apoptosis-related cysteine peptidase
  • Caspl

Background

Caspase-11 (also known as CASP11, CASP4, and ich-3) is one of several different types of caspases. The general role of caspases is to assist in cell death as well as inflammation. More specifically, caspase-11 is involved with pyroptotic cell death. Its structure is heterotrimeric, consisting of two antiparallel heterodimers. Novus offers Caspase 11 antibodies, Peptides and Proteins, Lysates, and RNAi.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Caspase-11 Antibody (NBP2-80099IR) (0)

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Secondary Antibodies

 

Isotype Controls

Additional Caspase-11 Products

Blogs on Caspase-11.

The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver
By Victoria Osinski, PhDWhat is the NLRP3 Inflammasome?With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome ...  Read full blog post.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release
By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...  Read full blog post.

Caspase 11 - A proinflammatory caspase that induces the innate immune response
While known for their role in programmed cell death, caspases are also essential for mediating inflammatory responses and innate immunity. Binding of microbial molecules by pattern recognition receptors triggers the formation of the multiprotein in...  Read full blog post.

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Bioinformatics

Gene Symbol Casp4