c-Myc Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human c-Myc is a 439 amino acid transcription factor with a bHLH/LZ (basic Helix-Loop-Helix, Leucine Zipper) domain. c-Myc DNA-binding and transcription function is achieved upon heterodimerization with its partner Max. c-Myc is often over-expressed and mutated in hematopoietic tumors. Mutations frequently result in truncations that remove the transactivation region or in the bHLH/LZ domain required for association with Max and DNA. Over the region used as immunogen, human c-Myc is 92% identical to the rat and mouse c-Myc proteins.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: ChIP, Western Blot.

Showing Publications 1 - 10 of 14. Show All 14 Publications. Collapse Publications.

Publications using AF3696	Applications	Species
Wang F, Gao Y, Xue S et al. SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity Nat Commun 9/22/2023 [PMID: 37739936]
Y Liang, X Liu, R Zhou, D Song, YZ Jiang, W Xue Chaetocin Promotes Osteogenic Differentiation via Modulating Wnt/Beta-Catenin Signaling in Mesenchymal Stem Cells Stem Cells International, 2021-02-06;2021(0):8888416. 2021-02-06 [PMID: 33628276] (Western Blot, Mouse)	Western Blot	Mouse
Greco CM, Cervantes M, Fustin JM et al. S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling Science advances 12/1/2020 [PMID: 33328229]
XF Liu, K Wang, HC Du LncRNA SNHG6 regulating Hedgehog signaling pathway and affecting the biological function of gallbladder carcinoma cells through targeting miR-26b-5p Eur Rev Med Pharmacol Sci, 2020-07-01;24(14):7598-7611. 2020-07-01 [PMID: 32744686] (Western Blot, Human)	Western Blot	Human
Zhiwei Luo, Xiaobing Qing, Christina Benda, Zhijian Huang, Meng Zhang, Yinghua Huang et al. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming Cell Regeneration 6/1/2019 [PMID: 31205685]
Harri M Itkonen, Alfonso Urbanucci, Sara ES Martin, Aziz Khan, Anthony Mathelier, Bernd Thiede et al. High OGT activity is essential for MYC-driven proliferation of prostate cancer cells Theranostics 4/12/2019 [PMID: 31149037]
Jing Luo, Yu Yao, Saiguang Ji, Qi Sun, Yang Xu, Kaichao Liu et al. PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/ beta -catenin signaling pathway Cancer Cell International 12/1/2019 [PMID: 31043858]
M Nagasaka, K Tsuzuki, Y Ozeki, M Tokugawa, N Ohoka, Y Inoue, H Hayashi Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc Biol. Pharm. Bull., 2019-01-01;42(3):481-488. 2019-01-01 [PMID: 30828079] (Western Blot, Human)	Western Blot	Human
Seth P, Hsieh PN, Jamal S et al. Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation Cell 2/21/2019 [PMID: 30794773]
Chronis C, Fiziev P, Papp B et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming Cell 1/26/2017 [PMID: 28111071]
Morrison G, Scognamiglio R, Trumpp A, Smith A Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification. EMBO J, 2015-12-16;35(3):356-68. 2015-12-16 [PMID: 26675138] (ChIP, Mouse)	ChIP	Mouse
Gong-Quan Li, Wen-Zhi Guo, Yi Zhang, Jing-Jing Seng, Hua-Peng Zhang, Xiu-Xian Ma et al. Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression Oncotarget 1/19/2016 [PMID: 26575167]
Tseng YY, Moriarity BS, Gong W et al. PVT1 dependence in cancer with MYC copy-number increase. Nature 8/7/2014 [PMID: 25043044]
Dilli Ram Bhandari, Kwang-Won Seo, Ji-Won Jung, Hyung-Sik Kim, Se-Ran Yang, Kyung-Sun Kang The regulatory role of c-MYC on HDAC2 and PcG expression in human multipotent stem cells Journal of Cellular and Molecular Medicine 7/1/2011 [PMID: 20716118]
Show All 14 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	IF	Human	02/02/2015	View Summary Application Immunofluorescence Sample Tested U266 and normal T cells Species Human Lot XYX0514031
	4 reviewed by: Verified Customer	ChIP	Human	01/08/2015	View Summary Application Chromatin Immunoprecipitation Sample Tested See PMID 23159369 Species Human

Array AF3696

• c-Myc Antibodies
• c-Myc ELISA Kits
• c-Myc Lysate
• c-Myc Proteins