Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein

CD137L is a member of the TNF superfamily and provides costimulatory signals to T cells. It is expressed on dendritic cells, activated macrophages, and B cells. CD137L binds to its receptor CD137 on activated T cells, this interaction is important for adaptive T-cell response. The engagement of CD137 by CD137L provides costimulation to both CD4+ and CD8+ cells. Agonist anti-CD137 monoclonal antibodies also have been used to stimulate CD137 to regulate T-cell number and functions. The Fc-CD137L fusion protein was generated by cloning the extracellular domain of mouse CD137L with the Fc region of mouse immunoglobulin (hinge region, CH2, CH3 domains). The Fc-CD137L fusion protein has comparable biological activities as 2A, a CD137 agonist antibody.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Publication using NBP2-26580	Applications	Species
Zhang N, Sadun RE, Arias RS et al. Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors. Clin Cancer Res. 2007-05-01 [PMID: 17460060]

Array NBP2-26580

• 4-1BB Ligand/TNFSF9 Antibodies
• 4-1BB Ligand/TNFSF9 Lysate
• 4-1BB Ligand/TNFSF9 Proteins
• 4-1BB Ligand/TNFSF9 Proteins and Enzymes