Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein Summary
Description |
A recombinant protein corresponding to TNFSF9. Amino Acid Sequence: EPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGKSGRTEPRPALTITTSPNLGTRENNADQVTPVSHIGCPNTTQQGSPVFAKLLAKNQASLCNTTLNWHSQDGAGSSYLSQGLRYEEDKKELVVDSPGLYYVFLELKLSPTFTNTGHKVQGWVSLVLQAKPQVDDFDNLALTVELFPCSMENKLVDRSWSQLLLLKAGHRLSVGLRAYLHGAQDAYRDWELSYPNTTSFGLFLVKPDNPWE Mouse Ig-Fc amino acid sequences are in ItalicsLinker sequence (SGR) in boldMouse CD137L sequences are underlined |
Details of Functionality |
In vitro proliferation assay, in vivo assays. |
Protein/Peptide Type |
Recombinant Protein |
Gene |
TNFSF9 |
Purity |
Protein A purified |
Endotoxin Note |
Endotoxin level < 0.1 EU/ug of the protein (< 0.01 ng/ug of the protein) as determined by the LAL test. |
Applications/Dilutions
Packaging, Storage & Formulations
Storage |
Store at -80C. Avoid freeze-thaw cycles. |
Buffer |
Phosphate-buffered solution, pH 7.2, containing no preservative. 0.2 um filter sterilized. |
Concentration |
2.0 mg/ml |
Purity |
Protein A purified |
Alternate Names for Recombinant Mouse 4-1BB Ligand/TNFSF9 Protein
Background
CD137L is a member of the TNF superfamily and provides costimulatory signals to T cells. It is expressed on dendritic cells, activated macrophages, and B cells. CD137L binds to its receptor CD137 on activated T cells, this interaction is important for adaptive T-cell response. The engagement of CD137 by CD137L provides costimulation to both CD4+ and CD8+ cells. Agonist anti-CD137 monoclonal antibodies also have been used to stimulate CD137 to regulate T-cell number and functions. The Fc-CD137L fusion protein was generated by cloning the extracellular domain of mouse CD137L with the Fc region of mouse immunoglobulin (hinge region, CH2, CH3 domains). The Fc-CD137L fusion protein has comparable biological activities as 2A, a CD137 agonist antibody.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are
guaranteed for 3 months from date of receipt.
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