PML Protein Products

Description

PML Protein is encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Bioinformatics

Entrez	5371 Human
Uniprot	AAH00080 Human NP_150242 Human P29590 Human
Product By Gene ID	5371
Alternate Names	MYLPP8675 Promyelocytic leukemia protein promyelocytic leukemia RING finger protein 71 RNF71probable transcription factor PML TRIM19promyelocytic leukemia, inducer of tripartite motif protein TRIM19 Tripartite motif-containing protein 19

Research Areas for PML Protein

Find related products by research area and learn more about each of the different research areas below.

Cancer
Zinc Finger