Pax3 Products

Description

PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These proteins play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.

Bioinformatics

Uniprot	NP_000429 Human NP_000429.2 Human NP_852122 Human NP_852123 Human NP_852123.1 Human P23760 Human
Product By Gene ID	5077
Alternate Names	CDHS HuP2 HUP2MGC120384 MGC120381 MGC120382 MGC120383 MGC134778 paired box 3 paired box gene 3 (Waardenburg syndrome 1) paired box homeotic gene 3 paired box protein Pax-3 paired domain gene 3 paired domain gene HuP2 Waardenburg syndrome 1 WS1 WS3

Research Areas for Pax3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Mesenchymal Stem Cell Markers
Neuronal Stem Cell Markers
Stem Cell Markers
Transcription Factors and Regulators

Related Pax3 Blog Posts

Check out the latest blog posts on Pax3.

FOXO1/FKHR (fork head in Rhabdomyosarcoma) FOXO1 belongs to the very large Forkhead family of transcription factors which contain a conserved distinct DNA-binding domain known as the Forkhead Box, or FOX. The Forkhead domain is a 100 amino acid long motif capable of binding and bending DNA,...    Read more.

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