Pancreatic Polypeptide/PP Antibody

Gene ID: 5539 This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: IB, ICC/IF, IF/IHC, IHC-Fr, IHC-P.

Showing Publications 1 - 10 of 19. Show All 19 Publications. Collapse Publications.

Publications using NB100-1793	Applications	Species
Wang S The cell autonomous and cell non-automous roles of YAP1 during pancreatogenesis Thesis 2023-01-01
Tixi W, Maldonado M, Chang YT et al. Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation eLife 2023-08-23 [PMID: 37610090]
van Gurp L, Fodoulian L, Oropeza D et al. Generation of human islet cell type-specific identity genesets Nature communications [PMID: 35440614] (IHC-P, Human)	IHC-P	Human
Rovira M, Maestro Ma, Grau V, Ferrer J Hnf1b-CreER causes efficient recombination of a Rosa26-RFP reporter in duct and islet delta cells Islets 2021-07-20 [PMID: 34282714]
Tang X, Uhl S, Zhang T et al. SARS-CoV-2 infection induces beta cell transdifferentiation Cell Metabolism 2021-05-01 [PMID: 34081913] (Human)		Human
Foo KS, Skowronski AA, Baum D et al. Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity Sci Rep 2019-03-21 [PMID: 30899071] (IHC-P, Mouse)	IHC-P	Mouse
Hara A, Nakagawa Y, Nakao K et al. Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide Endocr. J. 2019-03-06 [PMID: 30842364] (ICC/IF, Human)	ICC/IF	Human
Lu TT, Heyne S, Dror E et al. The Polycomb-Dependent Epigenome Controls b Cell Dysfunction, Dedifferentiation, and Diabetes Cell Metab. 2018-06-05 [PMID: 29754954] (IF/IHC, Mouse)	IF/IHC	Mouse
Hull RL, Gibson RL, McNamara S et al. Islet Interleukin-1beta Immunoreactivity Is an Early Feature of Cystic Fibrosis That May Contribute to beta-Cell Failure. Diabetes Care 2018-04-01 [PMID: 29437698] (Human)		Human
Kim-Muller Jy, Fan J, Kim Yj et al. Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic beta cells in diabetic mice. Nat Commun 2016-08-30 [PMID: 27572106] (IF/IHC, IB)	IF/IHC, IB
Cinti F, Bouchi R, Kim-Muller JY et al. Evidence of B-cell Dedifferentiation in Human Type 2 Diabetes. J. Clin. Endocrinol. Metab. 2015-12-29 [PMID: 26713822] (IHC-Fr, Human)	IHC-Fr	Human
Lee J, Sugiyama T, Liu Y et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. Elife. 2013-01-01 [PMID: 24252877] (IHC-Fr, Human)	IHC-Fr	Human
Sugiyama T, Benitez CM, Ghodasara A et al. Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation. Proc Natl Acad Sci U S A 2013-07-30 [PMID: 23852729] (IF/IHC, Mouse)	IF/IHC	Mouse
Qian J, Block GD, Colwell CS, Matveyenko AV. Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. Diabetes 2013-06-17 [PMID: 23775768]
Freeby M, Ichise M, Harris PE. Vesicular monoamine transporter, type 2 (vmat2) expression as it compares to insulin and pancreatic polypeptide in the head, body and tail of the human pancreas Islets 2012-11-01 [PMID: 23221614] (IF/IHC, ICC/IF, Human)	IF/IHC, ICC/IF	Human
Ono H, Yanagihara K, Sakamoto H et al. Prostate stem cell antigen gene is expressed in islets of pancreas Anat Cell Biol 2012-09-01 [PMID: 23094202] (ICC/IF, IF/IHC, Human)	ICC/IF, IF/IHC	Human
Desgraz R, Herrera PL. Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development;136(21):3567-74. 2009-11-01 [PMID: 19793886]
Saisho Y, Harris PE, Butler AE et al. Relationship between pancreatic vesicular monoamine transporter 2 (VMAT2) and insulin expression in human pancreas. J Mol Histol. 2008-10-01 [PMID: 18791800] (IHC-P, Human)	IHC-P	Human
Badman MK, Flier JS. The gut and energy balance: visceral allies in the obesity wars. Science 2005-03-25 [PMID: 15790843]
Show All 19 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Yves Heremans	IHC-P	Mouse	04/28/2016	View Summary Application Immunohistochemistry-Paraffin Sample Tested Mouse Pancreas Species Mouse
Enlarge	5 reviewed by: Bryan Tinsley	IHC-P		12/18/2013	View Summary Application Immunohistochemistry-Paraffin
Enlarge	5 reviewed by: Jonghyeob Lee	IHC-Fr	Mouse	08/21/2010	View Summary Application Immunohistochemistry-Frozen Sample Tested Mouse Adult Pancreas Tissue Species Mouse Lot P1

Array NB100-1793

• Pancreatic Polypeptide/PP Antibodies
• Pancreatic Polypeptide/PP ELISA Kits
• Pancreatic Polypeptide/PP Proteins