Species: Hu
Applications: WB, IHC, ELISA(Cap)
Host: Goat Polyclonal
Species: Mu
Applications: WB, B/N, ELISA(Cap)
Host: Goat Polyclonal
Species: Hu
Applications: WB, CyTOF-ready, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Mu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Mu
Applications: Bioactivity
Species: Pm-Cm, RM
Applications: Bioactivity
Description
The GPNMB gene codes for a type I transmembrane glycoprotein NBM. The GPNMB gene is present in lowly, but not highly, metastic human melanoma cell lines, therefore, it demonstrates involvement in development, proliferation, and differentiation of tissues. Isoform 1 is 572 amino acids long at a mass of nearly 64 kDA and isoform 2 exists at 560 amino acids long at approximately 62 kDA. This gene has been known to interact with various genes such as SMAD4, PLA2G4A, and ITSN2. GPNMB has been researched in its role in retinitis, lung cancer, melanoma, glioblastoma, glaucoma, and breast cancer.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
10457 |
| Alternate Names |
- glycoprotein (transmembrane) nmb
- glycoprotein NMB
- HGFINglycoprotein nmb-like protein
- NMBosteoactivin
- Transmembrane glycoprotein HGFIN
- transmembrane glycoprotein NMB
|
Research Areas for Osteoactivin/GPNMB
Find related products by research area and learn more about each of the different research areas below.
Cell Cycle and Replication
![Western Blot Osteoactivin/GPNMB Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Osteoactivin_AF2550_Western_Blot_19926.jpg)
![Immunohistochemistry Osteoactivin/GPNMB Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Osteoactivin_AF2550_Immunohistochemistry_15337.jpg)
![Neutralization Osteoactivin/GPNMB Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Osteoactivin_AF2330_Block_Neutralize_574.jpg)
![Intracellular Staining by Flow Cytometry Osteoactivin/GPNMB Antibody (303822) [Unconjugated]](http://images.novusbio.com/fullsize2/Osteoactivin_MAB25501_Flow_Cytometry_19990.jpg)
![N/A Osteoactivin/GPNMB [Biotin]](http://images.novusbio.com/fullsize2/DATA_Osteoactivin_DY2330_ELISA_1813.jpg)
![N/A Osteoactivin/GPNMB [Biotin]](http://images.novusbio.com/fullsize2/DATA_Osteoactivin_DY2550_ELISA_1844.jpg)
![SDS-PAGE Osteoactivin/GPNMB [Unconjugated]](http://images.novusbio.com/fullsize2/11154-ac_recombinant-cyno-rhesus-osteoactivin-gpnmb-fc-protein-cf-sds-page-18102022113358.jpg)