Ku80/XRCC5 Products

Description

Ku80, also known as XRCC5, plays a role in many diverse processes including cell signaling, proliferation, DNA repair, replication, transcriptional activation and apoptosis.

As one half of the heterodimer complex Ku, Ku80 is required for proper maintenance of the telomeric C strand. Ku80 also plays a role in DNA repair as an essential subunit of DNA-dependent protein kinase (DNA-PK) that phosphorylates certain transcription factors (Sp1, Oct-1 and p53). The heterodimer Ku binds double stranded DNA breaks for non-homologous end joining repair. Ku mutants are defective in T-DNA integration and over-expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.

Bioinformatics

Entrez	22596 Mouse 363247 Rat 7520 Human
Uniprot	AAH19027 Human AAH19027.1 Human NM_021141 Human NP_066964.1 Human P13010 Human Q4VBQ5 Human
Product By Gene ID	7520
Alternate Names	80kDa ATP-dependent DNA helicase 2 subunit 2 ATP-dependent DNA helicase II 80 kDa subunit CTC85 CTCBF EC 3.6.4.- FLJ39089 G22P2 KARP1 KARP-1 KU80 Ku80 Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen Ku86DNA repair protein XRCC5 KUB2 NFIV Thyroid-lupus autoantigen TLAA X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD) X-ray repair cross-complementing protein 5 X-ray repair, complementing defective, repair in Chinese hamster

Research Areas for Ku80/XRCC5

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Core ESC-Like Genes
DNA Double Strand Break Repair
DNA Repair
Non-homologous end-joining
Phospho-Specific
Stem Cell Markers