Species: Hu, Mu
Applications: WB
Host: Goat Polyclonal
Species: Hu, Rt
Applications: WB
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM]
Bioinformatics
| Entrez |
Mouse
Human
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
4793 |
| Alternate Names |
- beta
- IkappaBbeta
- I-kappa-B-beta
- IkB-B
- ikB-B
- IkB-beta
- IKBBikB-beta
- NF-kappa-B inhibitor beta
- NF-kappa-BIB
- nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor
- Thyroid receptor-interacting protein 9
- TR-interacting protein 9
- TRIP-9
- TRIP9ikappaBbeta
|
