HSP90 alpha Antibody

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP 90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP 90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, Ah receptor, and some kinases. Studies have shown that murine HSP 90 exists as two forms, HSP 84 and HSP 86, coded by related but separate genes, with 86% homologous amino acid sequences. These forms are analogous to the two forms of human HSP 90, HSP 89 beta and HSP 89 alpha. In an unstressed mouse fibroblast, the basal level of HSP 84 is found to be double that of HSP 86. However, after heat shock, HSP 86 shows a greater increase. Studies also suggest that upon cellular differentiation, the level of HSP 86, but not HSP 84, decreases. HSP 84 and HSP 86, which may be subject to estrogenic regulation, have been found as components of the non-DNA binding form of mouse glucocorticoid receptor, but dissociated from the transformed DNA-binding form.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NB120-2928	Applications	Species
Chang C, Tang X, Mosallaei D et al. LRP-1 receptor combines EGFR signalling and eHsp90 alpha autocrine to support constitutive breast cancer cell motility in absence of blood supply Scientific reports 2022-07-14 [PMID: 35835845]
Tang X, Chang C, Mosallaei D et al. Heterogeneous Responses and Isoform Compensation Dim Therapeutic Window of Hsp90 ATP-Binding Inhibitors in Cancer Molecular and cellular biology 2021-12-06 [PMID: 34871064]
He X, Smith SE, Chen S et al. Tumor-initiating stem cell shapes its microenvironment into an immunosuppressive barrier and pro-tumorigenic niche Cell reports 2021-09-07 [PMID: 34496236]
Tang X, Chang C, Hao M et al. Heat shock protein-90alpha (Hsp90 alpha) stabilizes hypoxia-inducible factor-1alpha (HIF-1alpha) in support of spermatogenesis and tumorigenesis Cancer gene therapy 2021-03-04 [PMID: 33664459]
M Bzowska, A Nogie?, K Bania, M Zygmunt, M Zar?bski, J Dobrucki, K Guzik Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages J. Leukoc. Biol., 2017-05-26;0(0):. 2017-05-26 [PMID: 28550115]
Deneka AY, Haber L, Kopp MC et al. Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model. PLoS ONE 2017-04-28 [PMID: 28453558] (IHC-P, Mouse)	IHC-P	Mouse
Smithline Zachary B, Nikonova Anna S, Hensley Harvey H et al. Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice. PLoS One. 2014-12-04 [PMID: 25474361] (IF/IHC, Mouse)	IF/IHC	Mouse
Seeger-Nukpezah T, Proia DA, Egleston BL et al. Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease. Proc Natl Acad Sci U S A 2013-07-30 [PMID: 23858461] (IHC-P, Mouse)	IHC-P	Mouse
Shelton SN, Shawgo ME, Matthews SB et al. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009-12-01 [PMID: 19741006]
De Nardo D, Masendycz P, Ho S et al. A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. J Biol Chem. 2005-03-01 [PMID: 15647277]
Peterson JK, Moran F, Conley AJ et al. Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex. Endocrinology. 2001-12-01 [PMID: 11713235]
Perdew GH, Hord N, Hollenback CE et al. Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells. Exp Cell Res. 1993-12-01 [PMID: 8262153]
Show All 12 Publications. Collapse Publications.

Array NB120-2928

• HSP90 alpha Antibodies
• HSP90 alpha ELISA Kits
• HSP90 alpha Lysates
• HSP90 alpha Protein
• HSP90 alpha Proteins and Enzyme