CSE1L/CAS/Exportin-2 Antibody (3D8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using H00001434-M08	Applications	Species
Lee WR, Shen SC, Wu PR et al. CSE1L Links cAMP/PKA and Ras/ERK pathways and regulates the expressions and phosphorylations of ERK1/2, CREB, and MITF in melanoma cells. Mol Carcinog 2015-09-01 [PMID: 26331446]
Okimoto S, Sun J, Fukuto A et al. hCAS/CSE1L regulates RAD51 distribution and focus formation for homologous recombinational repair. Genes Cells. 2015-06-30 [PMID: 26123175]
Lee WR, Shen SC, Shih YH5 et al. Early decline in serum phospho-CSE1L levels in vemurafenib/sunitinib-treated melanoma and sorafenib/lapatinib-treated colorectal tumor xenografts. J Transl Med. 2015-06-13 [PMID: 26070816]
Chin SY, Wu PR, Shih YH et al. High expression of cytoplasmic phosphorylated CSE1L in malignant melanoma but not in benign nevi: phosphorylated CSE1L for the discrimination between melanoma and benign nevi. Int J Clin Exp Pathol. 2015-01-01 [PMID: 25973023]
Jiang MC, Yeh CM, Tai CJ et al. CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression. Am J Surg. 2013-06-24 [PMID: 23806821]
Li KK, Yang L, Pang JC et al. MIR-137 Suppresses Growth and Invasion, is Downregulated in Oligodendroglial Tumors and Targets CSE1L. Brain Pathol. 2012-12-10 [PMID: 23252729]
Chang CC, Tai CJ, Su TC et al. The prognostic significance of nuclear CSE1L in urinary bladder urothelial carcinomas. Ann Diagn Pathol. 2012-04-02 [PMID: 22476051]
Uen WC, Tai CJ, Shen SC et al. Differential distributions of CSE1L/CAS and E-cadherin in the polarized and non-polarized epithelial glands of neoplastic colorectal epithelium. J Mol Histol. 2010-08-24 [PMID: 20734115]
Stella Tsai CS, Chen HC, Tung JN et al. Serum cellular apoptosis susceptibility protein is a potential prognostic marker for metastatic colorectal cancer. Am J Pathol. 2010-01-01 [PMID: 20150437]
Tung MC, Tsai CS, Tung JN et al. Higher Prevalence of Secretory CSE1L/CAS in Sera of Patients with Metastatic Cancer. Cancer Epidemiol Biomarkers Prev. 2009-05-01 [PMID: 19383891]
Tsao TY, Tsai CS, Tung JN et al. Function of CSE1L/CAS in the secretion of HT-29 human colorectal cells and its expression in human colon. Mol Cell Biochem. 2009-02-18 [PMID: 19224336]
Show All 11 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	IHC-P	Mouse	12/09/2021	View Summary Application Immunohistochemistry-Paraffin Sample Tested Prostate tissue Species Mouse Lot 3D8 Comments Comments Incubated samples with the primary antibody for 10 hours

Array H00001434-M08

• CSE1L/CAS/Exportin-2 Antibodies
• CSE1L/CAS/Exportin-2 Lysate
• CSE1L/CAS/Exportin-2 Proteins