WIPF1/WIP Products

Description

WIPF1 is involved in the organization of the actin cytoskeleton. The protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these WIPF1 and Wiskott-Aldrich syndrome protein may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. WIPF1 binds to Wiskott-Aldrich syndrome protein, profilin and actin. It is involved with NCK1 and GRB2 in the recruitment and activation of N-WASP and may be involved in regulating the subcellular localization of N-WASP, resulting in the disassembly of stress fibers in filopodia formation.

Bioinformatics

Entrez	117538 Rat 215280 Mouse 7456 Human
Uniprot	AAH02914.1 Human NM_003387 Human NP_001070737 Human NP_003378.3 Human O43516 Human
Product By Gene ID	7456
Alternate Names	WAS/WASL interacting protein family, member 1 WAS/WASL-interacting protein family member 1 WASP-interacting protein WASPIP WIPMGC111041 WiskProtein PRPL-2 WiskPRPL-2