VAMP-1 Products

Description

The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer®s disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP-1 is involved in subcellular vesicle targeting.

Bioinformatics

Entrez	22317 Mouse 25624 Rat 6843 Human
Uniprot	NM_199245 Human NP_055046 Human NP_058439 Human P23763 Human Q63666 Rat
Product By Gene ID	6843
Alternate Names	DKFZp686H12131 SYB1vesicle-associated membrane protein 1 synaptobrevin 1 Synaptobrevin-1 VAMP-1synaptobrevin-1 vesicle-associated membrane protein 1 (synaptobrevin 1)

Research Areas for VAMP-1

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones
Membrane Vesicle Markers
Neuronal Cell Markers
Neuroscience