UNC5H3/UNC5C Products

Description

UNC5C is a gene that codes for a protein that is the receptor for netrin that is required for axon guidance, as it mediates the axon repulsion of neuronal growth cones when there is ligand binding in the nervous system, and can also help to induce apoptosis. The protein encoded by UNC5C has two isoforms, with lengths of 931 and 597 amino acids and weights of approximately 103 and 66 kDa respectively. Current studies are being done on diseases and disorders related to this gene including colorectal cancer, renal cell carcinoma, rheumatoid arthritis, Parkinson's disease, kidney cancer, colon cancer, osteoarthritis, schizophrenia, and neuronitis. UNC5C has also been shown to have interactions with NTN1, PTPN11, DAPK1, DCC, and FYN in pathways such as the netrin signaling and axon guidance pathways.

Bioinformatics

Entrez	22253 Mouse 8633 Human
Uniprot	AAH41156 Human O95185 Human
Product By Gene ID	8633
Alternate Names	netrin receptor UNC5C Protein unc-5 homolog 3 Protein unc-5 homolog C unc-5 homolog 3 unc-5 homolog C (C. elegans) UNC5H3unc5 (C.elegans homolog) c

Research Areas for UNC5H3/UNC5C

Find related products by research area and learn more about each of the different research areas below.

Apoptosis