Species: Hu
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ELISA, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
29128 |
| Alternate Names |
- E3 ubiquitin-protein ligase UHRF1
- EC 6.3.2
- EC 6.3.2.-
- FLJ21925
- hNP95
- huNp95
- HuNp95
- ICBP90NP95
- Inverted CCAAT box-binding protein of 90 kDa
- Np95
- Nuclear protein 95
- Nuclear zinc finger protein Np95
- RING finger protein 106
- RNF106MGC138707
- Transcription factor ICBP90
- Ubiquitin-like PHD and RING finger domain-containing protein 1
- ubiquitin-like with PHD and ring finger domains 1
- ubiquitin-like, containing PHD and RING finger domains, 1
- Ubiquitin-like-containing PHD and RING finger domains protein 1
|
Research Areas for UHRF1
Find related products by research area and learn more about each of the different research areas below.
DNA RepairZinc Finger
