Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv
Applications: WB, ELISA, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
11277 |
| Alternate Names |
- 3'-5' exonuclease TREX1
- AGS1
- Aicardi-Goutieres syndrome 1
- CRV
- DKFZp434J0310
- DNase III
- DRN3
- EC 3.1.11.2
- HERNS
- three prime repair exonuclease 1,3' repair exonuclease 1
|
Related TREX1 Blog Posts
Check out the latest blog posts on TREX1.
Dinosaur Protein Names: Infographic
Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn... Read more.
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Trex1 (3'-5' exonuclease TREX1, DNase III)
This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui... Read more.
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Read more TREX1 related blogs.
