TBC1D1 Products

Description

TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.

Bioinformatics

Entrez	23216 Human
Uniprot	AAH50321.3 Human NM_015173 Human NP_055988 Human Q86TI0 Human
Product By Gene ID	23216
Alternate Names	KIAA1108TBC TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 TBC1 domain family member 1 TBC1

Related TBC1D1 Blog Posts

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Muscle-specific UBE2O ablation requires activated AMPK alpha 2 to protect against metabolic syndrome By Jamshed Arslan, Pharm. D., PhD. Generating energy (ATP) from nutrients is a recipe for life. One of the sensors of cellular energy levels is the serine/threonine kinase AMPK. This enzyme facilitates lipid oxidati...    Read more.

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