Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: IHC, CyTOF-ready, Flow
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22. The distribution of smoothelin positive cells indicates a correlation between smoothelin expression and smooth muscle tissue contractility. Smoothelin is a useful tool in the evaluation of atherosclerotic lesions.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Chicken
Human
Human
|
| Product By Gene ID |
6525 |
| Alternate Names |
- FLJ35365
- FLJ38597
- smoothelin
- SMSMO
|
![Immunohistochemistry Smoothelin Antibody (885424) [Unconjugated] - B](http://images.novusbio.com/fullsize2/Smoothelin_MAB8278_Immunohistochemistry_15331.jpg)
![Intracellular Staining by Flow Cytometry Smoothelin Antibody (885424) [Unconjugated] - B](http://images.novusbio.com/fullsize2/Smoothelin_MAB8278_Flow_Cytometry_19989.jpg)
