Smad4 Products

Description

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MadH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members.

Bioinformatics

Entrez	17128 Mouse 4089 Human 50554 Rat
Uniprot	AAH02379 Human BAB40977 Human NM_005359 Human NP_005350 Human NP_005350.1 Human Q13485 Human
Product By Gene ID	4089
Alternate Names	DPC4SMAD, mothers against DPP homolog 4 (Drosophila) hSMAD4 JIP MAD homolog 4 MADH4mothers against decapentaplegic homolog 4 mothers against decapentaplegic homolog 4 mothers against decapentaplegic, Drosophila, homolog of, 4 SMAD 4 SMAD family member 4MAD, mothers against decapentaplegic homolog 4 (Drosophila) SMAD, mothers against DPP homolog 4 Smad4

Research Areas for Smad4

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction
Stem Cell Signaling Pathway