Siglec-3/CD33 Products

Description

CD33 is a 67 kDa type I transmembrane glycoprotein and a member of the sialoadhesin family of cell surface receptors. It is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages, although it is absent on granulocytes. While it has been reported that CD33 can function as a sialic acid-dependent cell adhesion molecule, cells expressing CD33 require desialylation before they can bind cells bearing the appropriate sialoglycoconjugates. This suggests that inhibitory cis interactions may regulate or block any adhesion function. (1-4)

Bioinformatics

Entrez	945 Human
Uniprot	AAA51948 Human AAH28152 Human AAH28152.1 Human NM_001772 Human NP_001763 Human P20138 Human
Product By Gene ID	945
Alternate Names	CD33 antigen (gp67) CD33 antigen CD33 molecule FLJ00391 myeloid cell surface antigen CD33 p67 sialic acid binding Ig-like lectin 3 Sialic acid-binding Ig-like lectin 3 SIGLEC-3 Siglec-3 SIGLEC3gp67

Research Areas for Siglec-3/CD33

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Immunology

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